1-bromo-4-(2-methoxyethyl)benzene

Base Information

• Chemical Name: 1-bromo-4-(2-methoxyethyl)benzene
• CAS No.: 60835-90-7
• Molecular Formula: C9H11BrO
• Molecular Weight: 215.09
• Hs Code.: 2909309090
• Mol file: 60835-90-7.mol

Synonyms:2-(4-bromophenyl)ethyl methyl ether;methyl 4-bromophenyl ether;4-(2-methoxy)ethylbromobenzene;

Chemical Property of 1-bromo-4-(2-methoxyethyl)benzene

Chemical Property:

• PSA: 9.23000
• LogP: 2.63800

Purity/Quality:

99% ^*data from raw suppliers

1-Bromo-4-(2-methoxyethyl)benzene ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-bromo-4-(2-methoxyethyl)benzene

There total 7 articles about 1-bromo-4-(2-methoxyethyl)benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

4-bromophenethanol (4654-39-1) + methyl iodide (74-88-4) → p-bromo-β-methoxyethylbenzene (60835-90-7)

Guidance literature:

4-bromophenethanol; With sodium hydride; In N,N-dimethyl-formamide; at 0 ℃; for 0.166667h;

methyl iodide; In N,N-dimethyl-formamide; at 20 ℃; for 3h;

Reference yield: 80.0%

(4-bromo-phenyl)-acetic acid methyl ester (41841-16-1) → p-bromo-β-methoxyethylbenzene (60835-90-7)

Guidance literature:

With triethylsilane; trimethylsilyl trifluoromethanesulfonate; titanium tetrachloride; In dichloromethane; at 20 ℃; for 20h;

DOI:10.1016/S0040-4020(01)00420-3

Reference yield: 72.0%

methanol (67-56-1) + ethene (74-85-1) + 1-bromo-4-(trimethylsilyl)benzene (6999-03-7) → p-bromo-β-methoxyethylbenzene (60835-90-7)

Guidance literature:

methanol; ethene; 1-bromo-4-(trimethylsilyl)benzene; With (triphenylphosphine)gold(I) chloride; 1-(trifluoromethanesulfonyloxy)-1,2-benziodoxol-3(1H)-one; In acetonitrile; at 50 ℃; for 18h; under 750.075 Torr; Sealed tube;

methanol; With sodium hydroxide; In water; acetonitrile; at 40 ℃; for 4h;

DOI:10.1021/jacs.7b06668

upstream raw materials:

chloromethyl methyl ether

1-bromomethyl-4-bromobenzene

4-bromophenethanol

methyl iodide

Downstream raw materials:

4-(2-methoxyethyl)aniline

1-bromo-4-ethenyl-benzene

2-(4-(2-methoxyethyl)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

(2E,2'E)-diethyl 3,3'-(5-(methoxycarbonyl)-2-(2-methoxyethyl)-1,3-phenylene)diacrylate

Refernces

• 1、 -. "GLP-1 RECEPTOR MODULATORS". Paragraph 001032. . Retrieved 2016/06/28.
• 2、 Li, Gang,Leow, Dasheng,Wan, Li,Yu, Jin-Quan. "Ether-directed ortho-C-H olefination with a palladium(II)/monoprotected amino acid catalyst". supporting information. p. 1245 - 1247. Retrieved 2013/03/13.