5-Aminoindan

Base Information

• Chemical Name: 5-Aminoindan
• CAS No.: 24425-40-9
• Molecular Formula: C9H11N
• Molecular Weight: 133.193
• Hs Code.: 29214900
• European Community (EC) Number: 246-241-7
• UNII: Y4Z93Y93WJ
• DSSTox Substance ID: DTXSID80179182
• Nikkaji Number: J88.261E
• Wikidata: Q72438202
• Mol file: 24425-40-9.mol

Synonyms:5-Aminoindan;24425-40-9;2,3-dihydro-1H-inden-5-amine;Indan-5-amine;5-Indanamine;indan-5-ylamine;5-AMINOINDANE;5-Aminohydrindene;1H-Inden-5-amine, 2,3-dihydro-;MFCD00003803;Y4Z93Y93WJ;EINECS 246-241-7;5-Amino indane;5-Amino-indan;2,3-Dihydro-1H-inden-5-ylamine;5-Aminoindan, 95%;UNII-Y4Z93Y93WJ;SCHEMBL42805;LEWZOBYWGWKNCK-UHFFFAOYSA-;DTXSID80179182;AMY41842;STR00643;STL185588;2,3-Dihydro-1H-inden-5-ylamine #;AKOS000120832;AC-4784;BS-3771;A0991;CS-0088459;FT-0620015;EN300-20837;A817299;W-202020

Chemical Property of 5-Aminoindan

Chemical Property:

• Appearance/Colour: brown crystalline mass
• Vapor Pressure: 0.0237mmHg at 25°C
• Melting Point: 34-36 °C(lit.)
• Refractive Index: 1.574 - 1.576
• Boiling Point: 248.846 °C at 760 mmHg
• PKA: 5.17±0.20(Predicted)
• Flash Point: 128.313 °C
• PSA: 26.02000
• Density: 1.103 g/cm³
• LogP: 2.33870
• Storage Temp.: 0-10°C
• Water Solubility.: SLIGHTLY SOLUBLE
• XLogP3: 2.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 133.089149355
• Heavy Atom Count: 10
• Complexity: 122

Purity/Quality:

98%,99%, ^*data from raw suppliers

5-Aminoindan ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 20/21/22
• Safety Statements: 36-36/37

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C1CC2=C(C1)C=C(C=C2)N
• Uses: 5-Aminoindan was used in the synthesis of ligand 18/18 (2-(5-aminoindan)-6-(5-aminoindan)-4-chloro-s-triazine).

Technology Process of 5-Aminoindan

There total 16 articles about 5-Aminoindan which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

tert-butyl N-(indan-5-yl)carbamate (695231-56-2) → indan-5-amine (24425-40-9)

Guidance literature:

With water; sodium t-butanolate; In tetrahydrofuran; Heating;

DOI:10.1016/j.tetlet.2003.11.108

Reference yield: 98.0%

5-nitro-1H-indene (41734-55-8) → indan-5-amine (24425-40-9)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In ethyl acetate; at 20 ℃;

DOI:10.3390/molecules22010032

Reference yield: 92.0%

5-nitroindane (7436-07-9,34517-17-4) → indan-5-amine (24425-40-9)

Guidance literature:

With triethylamine; In water; at 80 ℃; for 6h; chemoselective reaction; Inert atmosphere; Green chemistry;

DOI:10.1039/c4ra01333f

upstream raw materials:

INDANE

5-nitro-1H-indene

5-acetamidoindane

5-nitroindane

Downstream raw materials:

1-(5-indanyl)-3-phenoxycarbonylurea

N-(2,3-dihydro-1H-inden-5-yl)glycine benzyl ester

2-(4-hydroxy-phenyl)-N-indan-5-yl-acetamide

N-(2,3-dihydro-1H-inden-5-ylamino)benzoic acid

Refernces

• 1、 Tom, Norma J.,Simon, Wendy M.,Frost, Heather N.,Ewing, Marcus. "Deprotection of a primary Boc group under basic conditions". . p. 905 - 906. Retrieved 2004.
• 2、 Guan, Xianghong,Luo, Peihua,He, Qiaojun,Hu, Yongzhou,Ying, Huazhou. "Design, synthesis and evaluation of indene derivatives as retinoic acid receptor α agonists". . . Retrieved 2017/01/24.