695231-56-2Relevant articles and documents
BENZENE FUSED HETEROCYCLIC DERIVATIVE AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME
-
Paragraph 00218; 0020; 00221; 00222; 00223, (2019/04/09)
The present disclosure provides a benzene fused heterocyclic derivative of Formula (I): --?-?-? is a single or double bond; n is an integer of 0 or 1; A is -CH2-, -CH(OH)-, or - C(O)-; G is C or N; X is -CH2-, O, or -C(O)-; Y is alky
Conformationally constrained analogues of N′-(4-tert-butylbenzyl)-N-(4-methylsulfonylaminobenzyl)thiourea as TRPV1 antagonists
Lim, Ju-Ok,Jin, Mi-Kyoung,Ryu, HyungChul,Kang, Dong Wook,Lee, Jeewoo,Pearce, Larry V.,Tran, Richard,Toth, Attila,Blumberg, Peter M.
experimental part, p. 322 - 331 (2009/04/07)
A series of bicyclic analogues having indan and tetrahydronaphthalene templates in the A-region were designed as conformationally constrained analogues of our previously reported potent TRPV1 antagonists (1, 3). The activities for rat TRPV1 of the conformationally restricted analogues were moderately or markedly diminished, particularly in the case of the tetrahydronaphthalene analogues. The analysis indicated that steric constraints at the benzylic position in the bicyclic analogues may be an important factor for their unfavorable interaction with the receptor.
A New Generation of N-Aryl-N′-(1-alkyl-2-chloroethyl)ureas as Microtubule Disrupters: Synthesis, Antiproliferative Activity, and β-Tubulin Alkylation Kinetics
Mounetou, Emmanuelle,Legault, Jean,Lacroix, Jacques,Gaudreault, René C.
, p. 5055 - 5063 (2007/10/03)
New N-aryl-N′-2-chloroethylureas (CEUs) with enhanced cytotoxicity were developed as antimitotic agents potentially useful in cancer chemotherapy. Highly potent CEUs were obtained by introduction of a branched alkylating chain, the N′-(1-methyl-2-chloro)e
