PYRIDINE-2-ACETAMIDE

Base Information

• Chemical Name: PYRIDINE-2-ACETAMIDE
• CAS No.: 5451-39-8
• Molecular Formula: C7H8 N2 O
• Molecular Weight: 136.153
• Mol file: 5451-39-8.mol

Synonyms:2-(2-Pyridyl)acetamide;2-(Pyridin-2-yl)acetamide; NSC 18382; a-Pyridylacetamide; a-Pyridylethanamide

Chemical Property of PYRIDINE-2-ACETAMIDE

Chemical Property:

• Vapor Pressure: 0.000142mmHg at 25°C
• Melting Point: 118-120°C
• Boiling Point: 332.8°Cat760mmHg
• PKA: 15.87±0.40(Predicted)
• Flash Point: 155.1°C
• Density: 1.17g/cm³

Purity/Quality:

98% MIN ^*data from raw suppliers

2-PYRIDINE ACETAMIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2-Pyridineacetamide is used as pharmaceutical intermediate.

Technology Process of PYRIDINE-2-ACETAMIDE

There total 9 articles about PYRIDINE-2-ACETAMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

pyridine-2-acetonitrile (2739-97-1) → 2-(pyridine-2-yl)acetamide (5451-39-8)

Guidance literature:

With water; at 150 ℃; for 1.5h; under 5171.62 - 6205.94 Torr; Inert atmosphere; Microwave irradiation;

DOI:10.1002/cssc.201000280

Reference yield: 76.0%

ethyl 2-(pyridinyl-2)acetate (2739-98-2) → 2-(pyridine-2-yl)acetamide (5451-39-8)

Guidance literature:

With sodium methylate; formamide; In N,N-dimethyl-formamide; at 60 ℃; for 0.5h;

Reference yield:

methyl 2-pyridylacetate (1658-42-0) → 2-(pyridine-2-yl)acetamide (5451-39-8)

Guidance literature:

With ammonium hydroxide;

DOI:10.1021/ja01590a046

upstream raw materials:

methyl 2-pyridylacetate

ethyl 2-(pyridinyl-2)acetate

2-vinylpyridine

water

Downstream raw materials:

pyridine-2-acetonitrile

2-(pyridin-2-yl)-thioacetamide

ethyl 2-(pyridinyl-2)acetate

N-phenyl-2-(pyridin-2-yl)acetamide

Refernces

• 1、 Singh, Ravinder,Kumar, Ramesh. "Hydrolysis of nitrile in presence of different zeolite catalysts under microwave IR-radiation". experimental part. p. 1403 - 1404. Retrieved 2012/09/22.
• 2、 Garcia-Alvarez, Rocio,Diez, Josefina,Crochet, Pascale,Cadierno, Victorio. "Arene-ruthenium(II) complexes containing inexpensive tris(dimethylamino) phosphine: Highly efficient catalysts for the selective hydration of nitriles into amides". experimental part. p. 5442 - 5451. Retrieved 2011/12/13.