Thieno[2,3-b]pyridine (8CI,9CI)

Base Information

• Chemical Name: Thieno[2,3-b]pyridine (8CI,9CI)
• CAS No.: 272-23-1
• Molecular Formula: C7H5NS
• Molecular Weight: 135.189
• Hs Code.: 2934999090
• Mol file: 272-23-1.mol

Synonyms:NSC 152397;

Chemical Property of Thieno[2,3-b]pyridine (8CI,9CI)

Chemical Property:

• Vapor Pressure: 0.0725mmHg at 25°C
• Refractive Index: 1.689
• Boiling Point: 236.5 °C at 760 mmHg
• PKA: 4.54±0.30(Predicted)
• Flash Point: 100.2 °C
• PSA: 41.13000
• Density: 1.272 g/cm³
• LogP: 2.29630
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature

Purity/Quality:

98% ^*data from raw suppliers

thieno[2,3-b]pyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Thieno[2,3-b]pyridine (8CI,9CI)

There total 20 articles about Thieno[2,3-b]pyridine (8CI,9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

6-bromo-2-chlorothieno<2,3-b>pyridine (68236-35-1) → thieno[2,3-b]pyridine (272-23-1)

Guidance literature:

With sodium hydroxide; zinc; Ambient temperature;

DOI:10.1039/P19810002509

Reference yield: 79.0%

4,6-dichlorothieno<2,3-b>pyridine (99429-80-8) → thieno[2,3-b]pyridine (272-23-1)

Guidance literature:

With acetic acid; zinc; for 1h; Heating;

Reference yield: 44.0%

2-nitrothiophene (609-40-5) + malondialdehyde bis(diethyl acetal) (122-31-6) → thieno[2,3-b]pyridine (272-23-1)

Guidance literature:

2-nitrothiophene; With hydrogenchloride; tin; zinc(II) chloride; In ethanol; water; at 30 - 85 ℃;

malondialdehyde bis(diethyl acetal); In ethanol; water; at 85 ℃; for 1h;

DOI:10.1016/j.tetlet.2017.04.021

upstream raw materials:

thieno[2,3-b]pyridine-2-carboxylic acid

6-bromo-2-chlorothieno<2,3-b>pyridine

4,6-dichlorothieno<2,3-b>pyridine

2-Bromo-3-[1,3]dithian-2-ylidenemethyl-pyridine

Downstream raw materials:

thieno[2,3-b]pyridine-3-carbonitrile

thieno[2,3-b]pyridine-6-carboxylic acid

2-bromothieno[2,3-b]pyridine

2-ethylthieno[2,3-b]pyridine

Refernces

• 1、 -. "Five-membered heterocyclic oxo carboxylic acid compound and medical application thereof". Paragraph 0828-0832. . Retrieved 2021/05/01.
• 2、 García-Carrillo, Mario Alfredo,Guzmán, ángel,Díaz, Eduardo. "Metal free coupling of heteroaryl N-tosylhydrazones and thiols: Efficient synthesis of sulfides". supporting information. p. 1952 - 1956. Retrieved 2017/04/27.