thieno[2,3-b]pyridine-6-carboxylic acid

Base Information

• Chemical Name: thieno[2,3-b]pyridine-6-carboxylic acid
• CAS No.: 478148-97-9
• Molecular Formula: C₈H₅NO₂S
• Molecular Weight: 179.199
• Mol file: 478148-97-9.mol

Synonyms:

Chemical Property of thieno[2,3-b]pyridine-6-carboxylic acid

Chemical Property:

Purity/Quality:

Thieno[2,3-b]pyridine-6-carboxylicacid 97.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of thieno[2,3-b]pyridine-6-carboxylic acid

There total 3 articles about thieno[2,3-b]pyridine-6-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

6-cyanothieno<2,3-b>pyridine (86344-86-7) → thieno[2,3-b]pyridine-6-carboxylic acid (478148-97-9)

Guidance literature:

With sodium hydroxide; In ethanol; water;

Reference yield: 6.0%

trimethylsilyl cyanide (7677-24-9) + thieno<2,3-b>pyridine 7-oxide (25557-50-0) → thieno[2,3-b]pyridine-6-carboxylic acid (478148-97-9) + thieno[2,3-b]pyridine-4-carboxylic acid

Guidance literature:

trimethylsilyl cyanide; thieno<2,3-b>pyridine 7-oxide; With N,N-Dimethylcarbamoyl chloride; In acetonitrile; at 100 ℃; for 4h;

With hydrogenchloride; In water; at 90 ℃;

Reference yield:

thieno[2,3-b]pyridine (272-23-1) → thieno[2,3-b]pyridine-6-carboxylic acid (478148-97-9) + thieno[2,3-b]pyridine-4-carboxylic acid

Guidance literature:

Multi-step reaction with 2 steps

1.1: urea hydrogen peroxide adduct; trifluoroacetic anhydride / dichloromethane / 48 h / 0 - 20 °C

2.1: N,N-Dimethylcarbamoyl chloride / acetonitrile / 4 h / 100 °C

2.2: 90 °C

With urea hydrogen peroxide adduct; trifluoroacetic anhydride; N,N-Dimethylcarbamoyl chloride; In dichloromethane; acetonitrile;

upstream raw materials:

6-cyanothieno<2,3-b>pyridine

thieno[2,3-b]pyridine

trimethylsilyl cyanide

thieno<2,3-b>pyridine 7-oxide

Refernces

• 1、 -. "Azabicyclic-substituted fused-heteroaryl compounds for the treatment of disease". . . Retrieved 2008/06/13.