Acetic acid,2,2'-[1,2-phenylenebis(oxy)]bis-, 1,1'-dimethyl ester

Base Information

• Chemical Name: Acetic acid,2,2'-[1,2-phenylenebis(oxy)]bis-, 1,1'-dimethyl ester
• CAS No.: 27648-87-9
• Molecular Formula: C12H14 O6
• Molecular Weight: 254.24
• Mol file: 27648-87-9.mol

Synonyms:Aceticacid, (o-phenylenedioxy)di-, dimethyl ester (8CI); Acetic acid,2,2'-[1,2-phenylenebis(oxy)]bis-, dimethyl ester (9CI);1,2-Bis(methoxycarbonylmethoxy)benzene; Benzene-1,2-dioxyacetic acid dimethylester; NSC 406759

Chemical Property of Acetic acid,2,2'-[1,2-phenylenebis(oxy)]bis-, 1,1'-dimethyl ester

Chemical Property:

Purity/Quality:

99%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Acetic acid,2,2'-[1,2-phenylenebis(oxy)]bis-, 1,1'-dimethyl ester

There total 2 articles about Acetic acid,2,2'-[1,2-phenylenebis(oxy)]bis-, 1,1'-dimethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

benzene-1,2-diol (120-80-9,19481-10-8,37349-32-9) + bromoacetic acid methyl ester (96-32-2) → methyl 2-methoxycarbonylmethyloxyphenoxyacetate (27648-87-9)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 120 ℃; for 2h;

DOI:10.1002/hlca.200790085

Reference yield: 61.0%

benzene-1,2-diol (120-80-9,19481-10-8,37349-32-9) + methyl chloroacetate (96-34-4) → methyl 2-methoxycarbonylmethyloxyphenoxyacetate (27648-87-9)

Guidance literature:

With potassium carbonate; potassium iodide; In methanol;

DOI:10.1016/j.bmcl.2006.11.058

Reference yield: 48.0%

methyl 2-methoxycarbonylmethyloxyphenoxyacetate (27648-87-9) → methyl (4-iodo-2-methoxycarbonylmethoxy-phenoxy)acetate (779340-90-8)

Guidance literature:

With Iodine monochloride; In acetonitrile; at 25 ℃; for 24h;

DOI:10.1002/adsc.200404024

upstream raw materials:

benzene-1,2-diol

methyl chloroacetate

bromoacetic acid methyl ester

Downstream raw materials:

2-[2-(2-hydroxy-2-oxoethoxy)phenoxy]acetic acid

methyl (4-iodo-2-methoxycarbonylmethoxy-phenoxy)acetate

N-(3-dimethylamino-3,4-dihydro-2H-benzo[b][1,4]dioxepin-3-ylmethyl)-2-(4-oxo-cyclohexyl)-acetamide

Refernces

• 1、 Sonda, Shuji,Katayama, Kenichi,Fujio, Masakazu,Sakashita, Hiroshi,Inaba, Kenichi,Asano, Kiyoshi,Akira, Toshiaki. "1,5-Benzodioxepin derivatives as a novel class of muscarinic M3 receptor antagonists". . p. 925 - 931. Retrieved 2007/10/03.
• 2、 Lal, Bansi,Gangopadhyay, Ashok K.,Jagtap,Tanpure, Rajendra,Rao,Gupte, Ravindra D.,Subbarayan,Asudani, Gope. "Guanidino substituted isoindolones as novel glycoprotein IIb-IIIa receptor antagonists". . p. 1815 - 1832. Retrieved 2008/09/18.