(NZ)-N-[1-(5,6,7,8-tetrahydronaphthalen-2-yl)ethylidene]hydroxylamine

Base Information

• Chemical Name: (NZ)-N-[1-(5,6,7,8-tetrahydronaphthalen-2-yl)ethylidene]hydroxylamine
• CAS No.: 7357-12-2
• Molecular Formula: C12H15 N O
• Molecular Weight: 189.257
• Hs Code.: 2928000090
• NSC Number: 46651
• Mol file: 7357-12-2.mol

Synonyms:(NZ)-N-[1-(5,6,7,8-tetrahydronaphthalen-2-yl)ethylidene]hydroxylamine;(E)-N-[1-(5,6,7,8-tetrahydronaphthalen-2-yl)ethylidene]hydroxylamine;1265612-60-9;NSC46651;NSC-46651;(E)-1-(5,6,7,8-tetrahydronaphthalen-2-yl)ethanoneoxime

Chemical Property of (NZ)-N-[1-(5,6,7,8-tetrahydronaphthalen-2-yl)ethylidene]hydroxylamine

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 104 °C
• Boiling Point: 336.379°C at 760 mmHg
• Flash Point: 208.041°C
• PSA: 32.59000
• Density: 1.114g/cm³
• LogP: 2.76360
• XLogP3: 3.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 189.115364102
• Heavy Atom Count: 14
• Complexity: 224

Purity/Quality:

99%min ^*data from raw suppliers

1-(5,6,7,8-Tetrahydronaphthalen-2-yl)ethanone oxime 90% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(=NO)C1=CC2=C(CCCC2)C=C1
• Isomeric SMILES: C/C(=N/O)/C1=CC2=C(CCCC2)C=C1

Technology Process of (NZ)-N-[1-(5,6,7,8-tetrahydronaphthalen-2-yl)ethylidene]hydroxylamine

There total 3 articles about (NZ)-N-[1-(5,6,7,8-tetrahydronaphthalen-2-yl)ethylidene]hydroxylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

6-Acetyl-1,2,3,4-tetrahydronaphthalene (774-55-0) → 1-(5,6,7,8-tetrahydronaphthanen-2-yl)ethanone oxime (7357-12-2)

Guidance literature:

With hydroxylamine hydrochloride; sodium acetate; In ethanol; water; for 3h; Reflux;

DOI:10.1021/jm8016249

Reference yield:

6-Acetyl-1,2,3,4-tetrahydronaphthalene (774-55-0) → 1-(5,6,7,8-tetrahydro-[2]naphthyl)-ethanone oxime (7357-12-2)

Guidance literature:

With hydroxylamine hydrochloride; sodium acetate; In methanol; diethyl ether;

Reference yield:

→ 1-(5,6,7,8-tetrahydronaphthanen-2-yl)ethanone oxime (7357-12-2)

Guidance literature:

With pyridine; hydroxylamine hydrochloride; In ethanol; for 4h; Reflux;

upstream raw materials:

6-Acetyl-1,2,3,4-tetrahydronaphthalene

Downstream raw materials:

N-(5,6,7,8-tetrahydronaphth-2-yl)acetamide

4-phenyl-2,6-bis(5,6,7,8-tetrahydronaphthalen-2-yl)pyridine

4,4,5,5-tetramethyl-2-(5,6,7,8-tetrahydronaphthalen-2-yl)-1,3,2-dioxaborolane

Refernces

• 1、 Hu, Naifu,Zhao, Guoqing,Zhang, Yuanyuan,Liu, Xiangqian,Li, Guangyu,Tang, Wenjun. "Synthesis of chiral α-amino tertiary boronic esters by enantioselective hydroboration of α-arylenamides". supporting information. p. 6746 - 6749. Retrieved 2015/06/16.
• 2、 Zaware, Pandurang,Shah, Shailesh R.,Pingali, Harikishore,Makadia, Pankaj,Thube, Baban,Pola, Suresh,Patel, Darshit,Priyadarshini, Priyanka,Suthar, Dinesh,Shah, Maanan,Jamili, Jeevankumar,Sairam, Kalapatapu V.V.M.,Giri, Suresh,Patel, Lala,Patel, Harilal,Sudani, Hareshkumar,Patel, Hiren,Jain, Mukul,Patel, Pankaj,Bahekar, Rajesh. "Modulation of PPAR subtype selectivity. Part 2: Transforming PPARα/γ dual agonist into α selective PPAR agonist through bioisosteric modification". scheme or table. p. 628 - 632. Retrieved 2011/03/18.