774-55-0

Basic information

• Product Name: 6-ACETYLTETRAHYDRONAPHTHALENE
• Synonyms: 6-ACETYLTETRAHYDRONAPHTHALENE 97%;1-(5,6,7,8-Tetrahydronaphthalen-2-yl)ethanone, 6-Acetyltetralin;1-[(5,6,7,8-Tetrahydronaphthalene)-2-yl]ethanone;2-Acetyl-5,6,7,8-T;1-tetralin-6-ylethanone;6-Acetyl-1,2,3,4-tetrahydronaphthalene 97%;1-(5,6,7,8-tetrahydro-2-naphthalenyl)-ethanon;1-(5,6,7,8-tetrahydro-2-naphthalenyl)-Ethanone
• CAS NO: 774-55-0
• Molecular Formula: C₁₂H₁₄O
• Molecular Weight: 174.24
• EINECS: 212-266-7
• Product Categories: Aromatic Hydrocarbons (substituted) & Derivatives;Building Blocks;C11 to C12;Carbonyl Compounds;Chemical Synthesis;Ketones;Organic Building Blocks
• Mol File: 774-55-0.mol
• Article Data: 18

Chemical Properties

• Melting Point: -21°C
• Boiling Point: 119-121°C 2mm
• Flash Point: 119-121°C/2mm
• Appearance: /
• Density: 1,058 g/cm3
• Vapor Pressure: 0.00053mmHg at 25°C
• Refractive Index: 1.5610
• Storage Temp.: 2-8°C
• Water Solubility: Slightly soluble in water.
• BRN: 1241458
• CAS DataBase Reference: 6-ACETYLTETRAHYDRONAPHTHALENE(CAS DataBase Reference)
• NIST Chemistry Reference: 6-ACETYLTETRAHYDRONAPHTHALENE(774-55-0)
• EPA Substance Registry System: 6-ACETYLTETRAHYDRONAPHTHALENE(774-55-0)

Safety Data

• Hazard Codes: Xn,N
• Statements: 22-51/53
• Safety Statements: 61
• RIDADR: UN 3082 9/PG 3
• WGK Germany: 3
• TSCA: Yes
• Hazardous Substances Data: 774-55-0(Hazardous Substances Data)

Usage

Description

6-Acetyl-1,2,3,4-tetrahydronaphthalene is a chemical compound that features a unique structure with a naphthalene core and an acetyl group attached to the sixth carbon. It is known for its stability and resistance to discoloration, making it a valuable component in various applications.

Uses

Used in Fragrance Industry:
6-Acetyl-1,2,3,4-tetrahydronaphthalene is used as a novel methyl anthranilate in the fragrance industry. Its exceptional stability and resistance to discoloration make it an ideal choice for creating long-lasting and consistent scents in fine fragrances.
Used in Detergent and Fabric Softener Industry:
In the detergent and fabric softener industry, 6-acetyl-1,2,3,4-tetrahydronaphthalene is used as a key ingredient. Its stability ensures that the fragrances in these products remain consistent and do not fade over time, providing a pleasant scent experience for users.
Used in Cosmetics Industry:
6-Acetyl-1,2,3,4-tetrahydronaphthalene is used as a fragrance ingredient in antiperspirants and other cosmetic products. Its stability and resistance to discoloration contribute to the overall quality and performance of these products, ensuring that they maintain their scent and appearance.
Used as a Pharmaceutical Intermediate:
Beyond its applications in the fragrance and cosmetics industries, 6-acetyl-1,2,3,4-tetrahydronaphthalene also serves as a valuable pharmaceutical intermediate. Its unique chemical structure allows it to be used in the synthesis of various pharmaceutical compounds, contributing to the development of new medications and therapies.

InChI:InChI=1/C12H14O/c1-9(13)11-7-6-10-4-2-3-5-12(10)8-11/h6-8H,2-5H2,1H3

Upstream product

• 1573-17-7 2-butyn-1,4-diol diacetate 
• 75-36-5 acetyl chloride 
• 91-17-8 decalin 
• 119-64-2 tetralin 
• 64-19-7 acetic acid 
• 7446-70-0 aluminium trichloride 
• 69849-04-3 2-(1-ethoxyethoxy)-2-lithiopropanenitrile 
• 71-43-2 benzene 
• 34452-25-0 ω-chlorobutyn-2-yl acetate 
• 85-42-7 1,2-Cyclohexanedicarboxylic acid-anhydride 
• 2819-48-9 1,2-bis(methylene)cyclohexane 
• 23194-33-4 methyl 5,6,7,8-tetrahydronaphthalene-2-carboxylate 
• 93-08-3 methyl 2-naphthyl ketone 
• 1131-63-1 1,2,3,4-tetrahydro-2-naphthoic acid 

Downstream Products

• 87999-04-0 2-amino-4-(5,6,7,8-tetrahydro-2-naphthyl)-thiazole 
• 13052-99-8 5,6,7,8-tetrahydro-2-naphthylacetic acid 
• 51529-97-6 5,6,7,8-tetrahydronaphthalene-2-carbaldehyde 
• 125868-80-6 2-(o-Carboxybenzyl)-(6,7,8,9-tetrahydrobenzoindan)-1-on 
• 50878-03-0 N-(5,6,7,8-tetrahydronaphth-2-yl)acetamide 
• 66298-11-1 2-oxo-4-phenyl-6-(5,6,7,8-tetrahydro-naphthalen-2-yl)-1,2-dihydro-pyridine-3-carbonitrile 
• 195622-95-8 C₂₀H₂₀O 
• 1223576-74-6 3-(3,4-dimethoxyphenyl)-1-(5,6,7,8-tetrahydronaphthalen-2-yl)prop-2-en-1-one 
• 1223576-75-7 3-(4-bromophenyl)-1-(5,6,7,8-tetrahydronaphthalen-2-yl)prop-2-en-1-one 
• 1289514-07-3 3-(3-ethoxy-4-hydroxyphenyl)-1-(1,2,3,4-tetrahydronaphthalen-6-yl)prop-2-en-1-one 
• 1289514-30-2 4-(3-ethoxy-4-hydroxyphenyl)-6-(1,2,3,4-tetrahydronaphthalen-6-yl)-2-thioxo-1,2-dihydropyridine-3-carbonitrile 
• 1289514-15-3 4-(2,6-difluorophenyl)-6-(1,2,3,4-tetrahydronaphthalen-6-yl)-1,2-dihydropyrimidine-2-thione 
• 1289514-09-5 1-acetyl-4-(2,6-difluorophenyl)-3-(1,2,3,4-tetrahydronaphthalen-6-yl)-2-pyrazoline 
• 1289514-26-6 4-(2,6-difluorophenyl)-6-(1,2,3,4-tetrahydronaphthalen-6-yl)-2-thioxo-1,2-dihydropyridine-3-carbonitrile 

Relevant articles and documents

Nickel- and zinc-promoted [2 + 2 + 2] cycloaddition of diynes and α, β-enones

The [2 + 2 + 2] cycloaddition of diynes and enones occurred in the presence of both nickel and zinc together. This binary metal-mediated reaction had two interesting features: (1) a terminally unsubstituted diyne reacted with an enone to give an aromatic compound with the concomitant incorporation of two hydrogen atoms abstracted from an expected 1, 3-diene product into another molecule of the starting enone and (2) a trimethylsilyl-substituted diyne reacted with an equimolar amount of enone to regioselectively afford a 1, 3-diene, in which the trimethylsilyl group is adjacent to the carbonyl group.

Design, synthesis and biological evaluation of novel aryldiketo acids with enhanced antibacterial activity against multidrug resistant bacterial strains

Antimicrobial resistance (AMR) is a major health problem worldwide, because of ability of bacteria, fungi and viruses to evade known therapeutic agents used in treatment of infections. Aryldiketo acids (ADK) have shown antimicrobial activity against several resistant strains including Gram-positive Staphylococcus aureus bacteria. Our previous studies revealed that ADK analogues having bulky alkyl group in ortho position on a phenyl ring have up to ten times better activity than norfloxacin against the same strains. Rational modifications of analogues by introduction of hydrophobic substituents on the aromatic ring has led to more than tenfold increase in antibacterial activity against multidrug resistant Gram positive strains. To elucidate a potential mechanism of action for this potentially novel class of antimicrobials, several bacterial enzymes were identified as putative targets according to literature data and pharmacophoric similarity searches for potent ADK analogues. Among the seven bacterial targets chosen, the strongest favorable binding interactions were observed between most active analogue and S. aureus dehydrosqualene synthase and DNA gyrase. Furthermore, the docking results in combination with literature data suggest that these novel molecules could also target several other bacterial enzymes, including prenyl-transferases and methionine aminopeptidase. These results and our statistically significant 3D QSAR model could be used to guide the further design of more potent derivatives as well as in virtual screening for novel antibacterial agents.

Selective catalytic hydrogenation of polycyclic aromatic hydrocarbons promoted by ruthenium nanoparticles

Ru nanoparticles stabilised by PPh3 are efficient catalysts for hydrogenation of polycyclic aromatic hydrocarbons (PAHs) containing 2-4 rings under mild reaction conditions. These compounds were partially hydrogenated with good to excellent selectivities just by optimizing the reaction conditions. The influence of the nature of substituents present in different positions of naphthalene on the selectivity of hydrogenation was also studied. Hydrogenation of products containing substituents at position 1 is slower than that of products containing substituents at position 2. In all cases, hydrogenation takes place mainly on the less substituted ring.