N-BENZYL-2-HYDROXYACETAMIDE

Base Information

• Chemical Name: N-BENZYL-2-HYDROXYACETAMIDE
• CAS No.: 19340-77-3
• Molecular Formula: C9H11 N O2
• Molecular Weight: 165.192
• Hs Code.: 2924299090
• Mol file: 19340-77-3.mol

Synonyms:Glycolamide,N-benzyl- (6CI,7CI,8CI); 2-Hydroxy-N-(phenylmethyl)acetamide;N-Benzyl-2-hydroxyacetamide; N-Benzylglycolamide; NSC 26565

Chemical Property of N-BENZYL-2-HYDROXYACETAMIDE

Chemical Property:

• Vapor Pressure: 4.73E-07mmHg at 25°C
• Boiling Point: 398.1°Cat760mmHg
• Flash Point: 194.6°C
• PSA: 49.33000
• Density: 1.161g/cm³
• LogP: 0.68600

Purity/Quality:

99% ^*data from raw suppliers

N-benzyl-2-hydroxyacetamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-BENZYL-2-HYDROXYACETAMIDE

There total 28 articles about N-BENZYL-2-HYDROXYACETAMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

glycolic Acid (79-14-1) + benzylamine (100-46-9) → N-Phenylmethyl hydroxyacetamide (19340-77-3)

Guidance literature:

at 90 ℃; for 1h;

DOI:10.1080/00304940009356751

Reference yield: 82.0%

glycolamide (598-42-5) + benzylamine (100-46-9) → N-Phenylmethyl hydroxyacetamide (19340-77-3)

Guidance literature:

With Trimethyl borate; In acetonitrile; at 100 ℃; for 15h;

DOI:10.1039/c0ob01069c

Reference yield: 70.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + Benzyl isocyanide (88333-03-3,10340-91-7) → N-Phenylmethyl hydroxyacetamide (19340-77-3)

Guidance literature:

With 2-(hydroxymethyl)benzoic acid; In dichloromethane; Reflux;

DOI:10.1016/j.tetlet.2017.11.021

upstream raw materials:

glycolic acid methyl ester

benzylamine

ethyl 2-hydroxyacetate

2-phenyl-1,3-oxazolidin-4-one

Downstream raw materials:

N-p-Anisyl-N'-benzyloxamid

benzylcarbamoyloxy-acetic acid

N-benzyl-oxazolidine-2,4-dione

Phenylacetoxyessigsaeure-benzylamid

Refernces

• 1、 -. "ADENOSINE RECEPTOR BINDING COMPOUNDS". Paragraph 00399. . Retrieved 2020/02/06.
• 2、 Ben-David, Yehoshoa,Diskin-Posner, Yael,Milstein, David,Zhou, Quan-Quan,Zou, You-Quan. "Synthesis of oxalamides by acceptorless dehydrogenative coupling of ethylene glycol and amines and the reverse hydrogenation catalyzed by ruthenium". . p. 7188 - 7193. Retrieved 2020/07/23.