2-Hydroxyacetamide

Base Information

• Chemical Name: 2-Hydroxyacetamide
• CAS No.: 598-42-5
• Molecular Formula: C2H5NO2
• Molecular Weight: 75.0672
• Hs Code.: 2924199090
• European Community (EC) Number: 814-440-3
• NSC Number: 97323
• UNII: 18EAK3UR7C
• DSSTox Substance ID: DTXSID70208531
• Nikkaji Number: J2.717K
• Wikidata: Q27111657
• Metabolomics Workbench ID: 54159
• Mol file: 598-42-5.mol

Synonyms:glycolamide;glycollamide

Chemical Property of 2-Hydroxyacetamide

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 118-120 °C(lit.)
• Refractive Index: 1.461
• Boiling Point: 338.465 °C at 760 mmHg
• PKA: 13.28±0.10(Predicted)
• Flash Point: 158.498 °C
• PSA: 63.32000
• Density: 1.254 g/cm³
• LogP: -0.83570
• Storage Temp.: Sealed in dry,Room Temperature
• Water Solubility.: 413.5g/L(25 oC)
• XLogP3: -1.5
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 75.032028402
• Heavy Atom Count: 5
• Complexity: 42.9

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-Hydroxyacetamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C(C(=O)N)O
• Uses: Glycolamide may be used in the preparation of phosphoglycolamide.

Technology Process of 2-Hydroxyacetamide

There total 12 articles about 2-Hydroxyacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

glycolic acid ammonium salt (35249-89-9) → glycolic Acid (79-14-1) + glycolamide (598-42-5)

Guidance literature:

glycolic acid ammonium salt; at 140 - 150 ℃; for 5h;

With water; at 105 ℃; for 2h;

Reference yield: 7.0%

glycolonitrile (107-16-4) → glycolic Acid (79-14-1) + glycolamide (598-42-5)

Guidance literature:

With sodium tetrahydroxyborate; In water; at 80 ℃; for 2.33h;

DOI:10.1016/S0040-4039(00)95254-7

Reference yield:

potassium cyanide + carbon monoxide (201230-82-2) → serin (302-84-1,83245-15-2) + glycolamide (598-42-5) + lactate anion (113-21-3) + DL-glycerate (3131-59-7,17036-01-0,28600-37-5,51700-06-2,103683-01-8,383-86-8) + glycolate (666-14-8) + (+/-)-lactamide (598-81-2,2043-43-8,65144-02-7,89673-71-2) + glycine (56-40-6,18875-39-3,25718-94-9) + H-Gly-NH2 (598-41-4) + rac-Ala-OH (302-72-7,25191-17-7,18875-37-1) + alanine amide (4726-84-5)

Guidance literature:

With nickel(II) sulfate hexahydrate; calcium hydroxide; In water; at 145 ℃; for 20h; under 56255.6 Torr;

DOI:10.1016/j.tetlet.2009.12.084

upstream raw materials:

glycolonitrile

acetoxy-acetic acid ethyl ester

ammonia

butan-1-ol

Downstream raw materials:

phosphoglycolamide

2,4-oxazolidinedione

2-(4-chloro-2-methyl-phenoxymethyl)-oxazolidin-4-one

2-(4-chloro-phenoxymethyl)-oxazolidin-4-one

Refernces

• 1、 -. "Methanol or formaldehyde ammoxidizing method of synthesizing amide". Paragraph 0039; 0040; 0041. . Retrieved 2016/10/09.
• 2、 -. "METHOD FOR THE PRODUCTION OF GLYCOLIC ACID FROM AMMONIUM GLYCOLATE BY DIRECT DEAMMONIATION". Page/Page column 23-24. . Retrieved 2008/06/13.