Sulconazole

Base Information

• Chemical Name: Sulconazole
• CAS No.: 61318-90-9
• Molecular Formula: C18H15Cl3N2S
• Molecular Weight: 397.755
• Hs Code.: 2933290090
• European Community (EC) Number: 919-950-0
• UNII: 5D9HAA5Q5S
• DSSTox Substance ID: DTXSID8044129
• Nikkaji Number: J1.095.036H
• Wikipedia: Sulconazole
• Wikidata: Q2392530
• NCI Thesaurus Code: C61958
• RXCUI: 37319
• Pharos Ligand ID: P5LLT4F3P3PG
• Metabolomics Workbench ID: 67498
• ChEMBL ID: CHEMBL1221
• Mol file: 61318-90-9.mol

Synonyms:1-(beta-(4''-chlorobenzylthio)-2'4'-dichlorophenethyl)imidazole;Exelderm;Myk;sulconazole;sulconazole mononitrate;sulconazole nitrate;sulconazole, mononitrate, (+-)-isomer

Chemical Property of Sulconazole

Chemical Property:

• Appearance/Colour: white crystalline or crystalloid powder
• Vapor Pressure: 6.4E-12mmHg at 25°C
• Boiling Point: 558.2 °C at 760 mmHg
• PKA: 6.55±0.12(Predicted)
• Flash Point: 291.4 °C
• PSA: 43.12000
• Density: 1.34 g/cm³
• LogP: 6.51800
• Storage Temp.: 2-8°C
• XLogP3: 6.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 6
• Exact Mass: 396.002153
• Heavy Atom Count: 24
• Complexity: 379

Purity/Quality:

99% ^*data from raw suppliers

Sulconazole 98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=CC=C1CSC(CN2C=CN=C2)C3=C(C=C(C=C3)Cl)Cl)Cl
• uses: Sulconazole (Exelderm) is a synthetic, sulfur-substituted imidazole that is structurally related to the other imidazole antifungals (ketoconazole, econazole, and miconazole). It is postulated to inhibit 14-α-demethylase for decreased ergosterol synthesis, increased cell membrane permeability, and resultant cell death. It is active against most dermatophytes, yeast, and P. orbiculare. It also displays activity against some aerobic and anaerobic gram-positive bacteria. Sulconazole is a mild inducer of the cytochrome P-450 microsomal enzymes CYP1A1 and CYP2B1 and could theoretically induce the metabolism of other drugs.
• Indications: Sulconazole (Exelderm) is a synthetic, sulfur-substituted imidazole that is structurally related to the other imidazole antifungals (ketoconazole, econazole, and miconazole). It is postulated to inhibit 14-α-demethylase for decreased ergosterol synthesis, increased cell membrane permeability, and resultant cell death. It is active against most dermatophytes, yeast, and P. orbiculare. It also displays activity against some aerobic and anaerobic gram-positive bacteria. Sulconazole is a mild inducer of the cytochrome P-450 microsomal enzymes CYP1A1 and CYP2B1 and could theoretically induce the metabolism of other drugs.

Technology Process of Sulconazole

There total 1 articles about Sulconazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ sulconazole (61318-90-9,180185-78-8)

Guidance literature:

1-(2,4,β-Trichlor-phenylethyl)-imidazol + 4-Chlor-benzylmercaptan.;

Reference yield:

sulconazole (61318-90-9,180185-78-8) → (R)-sulconazole (180185-77-7,180185-78-8) + (S)-sulconazole (180185-78-8)

Guidance literature:

With diethylamine; In hexane; isopropyl alcohol; Resolution of racemate;

DOI:10.1096/fj.201900443RR

Reference yield:

sulconazole (61318-90-9,180185-78-8)

Guidance literature:

With UDP-glucoronic acid; alamethicin; magnesium chloride; D-Glucaro-1,4-lacton; at 4 - 37 ℃; pH=7.4; Reagent/catalyst; Kinetics; aq. buffer; Enzymatic reaction;

DOI:10.1124/dmd.109.030676

Downstream raw materials:

(R)-sulconazole

(S)-sulconazole

Refernces

• 1、 -. "Novel 1-phenethylimidazoles". . . Retrieved 2008/06/13.