20(R)-Propanaxadiol

Base Information Edit

Chemical Name:20(R)-Propanaxadiol
CAS No.:38243-03-7
Molecular Formula:C42H72O13
Molecular Weight:785.026
Hs Code.:
Mol file:38243-03-7.mol

Synonyms:(3b,12b,20R)-12,20-Dihydroxydammar-24-en-3-yl O-b-D-glucopyranosyl-(1?;20(R)-Ginsenoside Rg3;20(R)-Propanaxadiol;

Suppliers and Price of 20(R)-Propanaxadiol

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
20(R)-GinsenosideRg3
25mg
$ 95.00

TRC
20(R)-GinsenosideRg3
100mg
$ 275.00

Medical Isotopes, Inc.
(20R)-GinsenosideRg3
50 mg
$ 395.00

Medical Isotopes, Inc.
(20R)-GinsenosideRg3
250 mg
$ 700.00

JR MediChem
20(R)Ginsenoside?Rg3 98%
20mg
$ 1500.00

DC Chemicals
20(R)GinsenosideRg3 >98%,StandardReferencesGrade
20 mg
$ 280.00

Crysdot
20(R)-GinsenosideRg3 95+%
100mg
$ 200.00

Crysdot
20(R)-GinsenosideRg3 95+%
50mg
$ 120.00

Crysdot
20(R)-GinsenosideRg3 95+%
25mg
$ 80.00

ChemScene
20(R)-GinsenosideRg3 >98.0%
10mg
$ 80.00

Total 59 raw suppliers

Chemical Property of 20(R)-Propanaxadiol Edit

Chemical Property:

Melting Point:315-318 °C
Boiling Point:885 °C at 760 mmHg
PKA:12.85±0.70(Predicted)
Flash Point:489 °C
PSA：357.06000
Density:1.30 g/cm³
LogP:-1.56350
Storage Temp.:Hygroscopic, -20°C Freezer, Under inert atmosphere
Solubility.:Chloroform (Very Slightly, Heated Sonicated), Pyridine (Slightly, Heated, Sonica

Purity/Quality:

98%Min ^*data from raw suppliers

20(R)-GinsenosideRg3 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Description Ginsenoside Rg3 is mainly derived from the dried roots of Araliaceae Panax ginseng C.A.?Mey. and Panax quinquefolius L.?Ginseng has a long history of medicinal uses, well known as “king of herbs.” Ginseng is listed as the top grade in “Shen Nong’s herbal class,” with “the main security set up the five internal organs, spirit, soul, stop fright, in addition to evil, eyesight, fun puzzle” account. The traditional Chinese medicine regards ginseng as the top grade of reinforcing Qi, with Dabu strength, spleen and lungs, Sheng Jin, Anshen Yizhi, etc.
Physical properties Appearance: white powder. Density: 1.40. Melting point: 315–318°C. Solubility: 20(R)-ginsenoside Rg3 is soluble in methanol and ethanol; low water solubility; insoluble in ether and chloroform. Storage temperature: 2–8°C.The component classification belongs to three dammarane tetracyclic triterpenoid saponins.
Uses 20(R)-Ginsenoside Rg3 causes an inhibition of phosphatidylinositol 3-kinase/Akt activation that, in turn, results in modulations in Bcl-2 family proteins in such a way that the apoptosis of U87 cells are regulated. Elicits a significant inhibition of in vitro cell adhesion and invasion of U87 cells. in vitro stereoselective inhibition of ginsenosides toward UDP-glucuronosyltransferase isoforms and in vivo inhibition of tumor angiogenesis of lung cancer.
Indications This product is contained in “New drug standards” the 87th volume. Ginsenoside Rg3 capsule, ginsenoside Rg3 emulsion, and ginsenoside Rg3 microemulsion are mainly used in the clinical treatment or adjuvant therapy of lung cancer, breast cancer, liver cancer, gastric cancer, colon cancer, etc. In addition, they improve and prevent the common diseases in the elderly such as cardiovascular disease, coronary heart disease, limb weakness, difficulty walking, and loss of memory. Ginsenoside Rg3 also has a certain biological activity in antiviral, radiosensitization, and treatment of chronic obstructive pulmonary disease.
Clinical Use The basic research for many years and a large number of clinical data confirm that ginsenoside Rg3 effectively inhibits the growth of lung cancer, liver cancer, gastric cancer, colon cancer, and breast cancer, significantly improves the clinical symptoms of patients, improves the quality of life, and prevents and treats cancer. Ginsenoside Rg3 effectively improves the ability of anti-fatigue, antiaging, and resistance to disease. It also improves cardiovascular function, is resistant to platelet aggregation, protects nerve cells of brain, and improves immunity.Ginsenoside Rg3 is the active ingredient of Shenyi capsule which is a kind of traditional Chinese anticancer medicine developed in China. It prevents the metastasis and recurrence of cancer and has been an adjuvant treatment in multiple tumors . Shenyi capsule improves the curative effects of primary lung cancer and liver cancer, relieves the symptoms of Qi deficiency, as well as improves immunity, when combined with chemotherapy. Further study on the antitumor mechanism of ginsenoside Rg3 will be helpful to the clinical application of this drug.

Technology Process of 20(R)-Propanaxadiol

There total 28 articles about 20(R)-Propanaxadiol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%