Folienetriol

Base Information

• Chemical Name: Folienetriol
• CAS No.: 6892-79-1
• Molecular Formula: C30H52O3
• Molecular Weight: 460.741
• DSSTox Substance ID: DTXSID90988626
• Wikidata: Q82977252
• Mol file: 6892-79-1.mol

Synonyms:3-epibetulafolientriol;betulafolientriol;betulafolientriol, 3-epimer

Chemical Property of Folienetriol

Chemical Property:

• Vapor Pressure: 7.57E-15mmHg at 25°C
• Refractive Index: 1.528
• Boiling Point: 559.5 °C at 760 mmHg
• Flash Point: 226.1 °C
• PSA: 60.69000
• Density: 1.036 g/cm³
• LogP: 6.50060
• XLogP3: 7.2
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 460.39164552
• Heavy Atom Count: 33
• Complexity: 783

Purity/Quality:

99%, ^*data from raw suppliers

Folienetriol 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(=CCCC(C)(C1CCC2(C1C(CC3C2(CCC4C3(CCC(C4(C)C)O)C)C)O)C)O)C
• Isomeric SMILES: CC(=CCC[C@@](C)([C@H]1CC[C@]2([C@@H]1[C@@H](C[C@H]3[C@]2(CCC4[C@@]3(CC[C@H](C4(C)C)O)C)C)O)C)O)C

Technology Process of Folienetriol

There total 10 articles about Folienetriol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

12-β-O-hydroxy-20(S)-hydroxydammarane-24-ene-3-one (51116-90-6) → protopanaxadiol (6892-79-1,7755-01-3,30636-90-9,38243-15-1,53368-76-6,103834-30-6)

Guidance literature:

With sodium tetrahydroborate; In isopropyl alcohol;

DOI:10.1016/0008-6215(88)85045-6

Reference yield:

(20S)-dammar-24-ene-3α,12β,20-triol (6892-79-1) → protopanaxadiol (6892-79-1,7755-01-3,30636-90-9,38243-15-1,53368-76-6,103834-30-6)

Guidance literature:

Multi-step reaction with 2 steps

1: CrO₃; pyridine

2: NaBH₄ / propan-2-ol

With pyridine; chromium(VI) oxide; sodium tetrahydroborate; In isopropyl alcohol;

DOI:10.1007/s10600-006-0035-4

Reference yield:

(20S)-protopanaxadiol 3-O-(6-O-malonyl-β-D-glucopyranosyl-(1->2)-β-D-glucopyranoside) 20-O-β-D-xylopyranosyl-(1->3)-β-D-glucopyranosyl-(1->6)-β-D-glucopyranoside (1268481-62-4) → protopanaxadiol (6892-79-1,7755-01-3,30636-90-9,38243-15-1,53368-76-6,103834-30-6)

Guidance literature:

With hydrogenchloride; water; at 100 ℃; for 2h;

DOI:10.3390/molecules15042319

upstream raw materials:

12-β-O-hydroxy-20(S)-hydroxydammarane-24-ene-3-one

ginsenoside Rg₃

(20S)-protopanaxadiol 3-O-(6-O-malonyl-β-D-glucopyranosyl-(1->2)-β-D-glucopyranoside) 20-O-β-D-xylopyranosyl-(1->3)-β-D-glucopyranosyl-(1->6)-β-D-glucopyranoside

ginsenoside Rb₂

Downstream raw materials:

12-β-O-hydroxy-20(S)-hydroxydammarane-24-ene-3-one

20-hydroxy-3,12-dioxo-25,26,27-trinor-dammaran-24-oic acid-lactone

(14R)-dodecahydro-17-((S)-2-hydroxy-6-methylhept-5-en-2-yl)-4,4,8,10,14-pentamethyl-2H-cyclopenta[a]phenanthrene-3,12(4H,14H)-dione

protopanaxadiol

Refernces

• 1、 Bai, Yuping,Zhao, Lisha,Qu, Chenling,Meng, Xiangzhe,Zhang, Hanqi. "Microwave degradation of floatation-enriched ginsenoside extract from Panax quinquefolium L. Leaf". experimental part. p. 10252 - 10260. Retrieved 2010/07/18.
• 2、 Bae, Eun-Ah,Han, Myung Joo,Choo, Min-Kyung,Park, Sun-Young,Kim, Dong-Hyun. "Metabolism of 20(S)- and 20(R)-ginsenoside Rg3 by human intestinal bacteria and its relation to in vitro biological activities.". . p. 58 - 63. Retrieved 2007/10/03.