7,4'-DIHYDROXYFLAVONE

Base Information

• Chemical Name: 7,4'-DIHYDROXYFLAVONE
• CAS No.: 2196-14-7
• Molecular Formula: C15H10 O4
• Molecular Weight: 254.242
• Hs Code.: 2914501900
• Mol file: 2196-14-7.mol

Synonyms:Flavone,4',7-dihydroxy- (6CI,7CI,8CI); 4',7-Dihydroxyflavone; 7,4'-Dihydroxyflavone;7-Hydroxy-2-(4-Hydroxyphenyl)chromen-4-one

Chemical Property of 7,4'-DIHYDROXYFLAVONE

Chemical Property:

• Vapor Pressure: 3.87E-11mmHg at 25°C
• Melting Point: 324-325°C
• Boiling Point: 512.8°Cat760mmHg
• PKA: 7.03±0.40(Predicted)
• Flash Point: 201.2°C
• PSA: 70.67000
• Density: 1.443g/cm³
• LogP: 2.87120
• Storage Temp.: 2-8°C

Purity/Quality:

≥98% ^*data from raw suppliers

7-Hydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 7-Hydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one is used in methods related to bioactive agents that convert from anions to molecules.

Technology Process of 7,4'-DIHYDROXYFLAVONE

There total 48 articles about 7,4'-DIHYDROXYFLAVONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

1-[4-(tert-Butyl-dimethyl-silanyloxy)-phenyl]-3-(2,4-dihydroxy-phenyl)-propane-1,3-dione → 7,4'-Dihydroxyflavon (2196-14-7)

Guidance literature:

With sulfuric acid; In acetic acid; at 95 - 100 ℃; for 1h;

DOI:10.1021/jo00016a015

Reference yield: 87.0%

1-<2-hydroxy-4-(methoxymethoxy)phenyl>-3-<4-(methoxymethoxy)phenyl>propane-1,3-dione → 7,4'-Dihydroxyflavon (2196-14-7)

Guidance literature:

With Amberlyst 15 resin; In isopropyl alcohol; for 3h; Heating;

Reference yield: 75.0%

2-chloro-1-(2,4-dihydroxyphenyl)ethanone (25015-92-3) + 4-hydroxy-benzaldehyde (123-08-0,65581-83-1) → 7,4'-Dihydroxyflavon (2196-14-7)

Guidance literature:

With sodium hydroxide; In ethanol; water; at 20 ℃;

DOI:10.1016/j.bmc.2016.03.064

upstream raw materials:

4'-amino-7-hydroxyflavone

4,7-dihydroxy-3-(4-hydroxy-benzoyl)-coumarin

7-benzyloxy-4'-methoxyflavone

isoliquirtigenin

Downstream raw materials:

2-(4-hydroxyphenyl)-7-methoxychromen-4-one

4,7-dimethoxyflavone

7,4'-dihydroxy-dihydroflavone

kumatakenin B 8-C-β-D-glucoside

Refernces

• 1、 Durgapal, Sunil Dutt,Soman, Shubhangi S.,Umar, Shweta,Balakrishnan, Suresh. "Synthesis and studies of flavone and bis-flavone derivatives". . p. 2502 - 2510. Retrieved 2020.
• 2、 -. "A method of synthesizing the glycyrrhizin (by machine translation)". . . Retrieved 2019/03/24.