N1-(4-AMINO-2-METHYLPHENYL)ACETAMIDE

Base Information

• Chemical Name: N1-(4-AMINO-2-METHYLPHENYL)ACETAMIDE
• CAS No.: 56891-59-9
• Molecular Formula: C9H12 N2 O
• Molecular Weight: 164.207
• Hs Code.: 2924299090
• Mol file: 56891-59-9.mol

Synonyms:2-Acetamido-5-aminotoluene;4-Acetamido-3-methylaniline; 4'-Amino-2'-methylacetanilide;5-Amino-2-acetamidotoluene; N-(4-Amino-2-methylphenyl)acetamide;NSC 231662

Chemical Property of N1-(4-AMINO-2-METHYLPHENYL)ACETAMIDE

Chemical Property:

• Vapor Pressure: 0.0126mmHg at 25°C
• Melting Point: 141 °C
• Boiling Point: 259.9°Cat760mmHg
• PKA: 14.76±0.70(Predicted)
• Flash Point: 111°C
• PSA: 55.12000
• Density: 1.163g/cm³
• LogP: 2.18980
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

98%min ^*data from raw suppliers

N-(4-amino-2-methylphenyl)acetamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N1-(4-AMINO-2-METHYLPHENYL)ACETAMIDE

There total 4 articles about N1-(4-AMINO-2-METHYLPHENYL)ACETAMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

2-methyl-4-nitroacetanilide (2719-15-5) → N-(4-Amino-2-methyl-phenyl)-acetamide (56891-59-9)

Guidance literature:

With sodium formate; In ethanol; at 85 ℃; for 1h;

DOI:10.1002/cctc.201700609

Reference yield:

2-methyl-4-nitro-benzenamine (99-52-5) → N-(4-Amino-2-methyl-phenyl)-acetamide (56891-59-9)

Guidance literature:

Multi-step reaction with 2 steps

1: tetrahydrofuran / 12 h / 0 - 80 °C / Inert atmosphere

2: palladium on activated charcoal; hydrogen / methanol / 12 h / 16 °C / Inert atmosphere

With palladium on activated charcoal; hydrogen; In tetrahydrofuran; methanol;

Reference yield:

acetic anhydride (108-24-7) + 2-methyl-p-phenylenediamine (95-70-5) → N-(4-Amino-3-methyl-phenyl)-acetamide (6375-20-8) + N-(4-Amino-2-methyl-phenyl)-acetamide (56891-59-9)

Guidance literature:

With water; das entstandene Diacetylderivat durch mehrstuendiges Kochen mit natronlauge verseift;

DOI:10.1111/j.1475-4991.2000.tb00954.x

upstream raw materials:

2-methyl-4-nitroacetanilide

acetic anhydride

2-methyl-p-phenylenediamine

2-methyl-4-nitro-benzenamine

Downstream raw materials:

C₁₄H₁₈N₄O₅

2,7-dimethylquinoline

C₁₆H₂₃N₅O₇S

C₁₇H₂₅N₅O₆S

Refernces

• 1、 Kunfi, Attila,Szabó, Vivien,Mastalir, ágnes,Bucsi, Imre,Mohai, Miklós,Németh, Péter,Bertóti, Imre,London, Gábor. "Palladium on Polydopamine: Its True Potential in Catalytic Transfer Hydrogenations and Heck Coupling Reactions". supporting information. p. 3236 - 3244. Retrieved 2017/08/29.
• 2、 -. "Process for preparing 4-amino-3-methyl-N-substituted or unsubstituted alkylanilines". . . Retrieved 2008/06/13.