2-methyl-N-(4-nitrophenyl)propanamide

Base Information

• Chemical Name: 2-methyl-N-(4-nitrophenyl)propanamide
• CAS No.: 7160-11-4
• Molecular Formula: C10H12 N2 O3
• Molecular Weight: 208.217
• Mol file: 7160-11-4.mol

Synonyms:Propionanilide,2-methyl-4'-nitro- (7CI,8CI); NSC 15665

Chemical Property of 2-methyl-N-(4-nitrophenyl)propanamide

Chemical Property:

• Vapor Pressure: 6.79E-07mmHg at 25°C
• Melting Point: 167-169 °C
• Boiling Point: 408.9°C at 760 mmHg
• PKA: 13.67±0.70(Predicted)
• Flash Point: 201.1°C
• PSA: 74.92000
• Density: 1.241g/cm³
• LogP: 2.78550

Purity/Quality:

99%min ^*data from raw suppliers

2-methyl-N-(4-nitrophenyl)propanamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-methyl-N-(4-nitrophenyl)propanamide

There total 5 articles about 2-methyl-N-(4-nitrophenyl)propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

ISOPROPYLAMIDE (563-83-7) + nitrobenzene (98-95-3,26969-40-4) → N-(4-nitrophenyl)isobutyramide (7160-11-4) + trans-azoxybenzene (20972-43-4,21650-65-7,495-48-7,55599-32-1)

Guidance literature:

With tetramethyl ammoniumhydroxide; at 70 ℃; for 4h; under 40 Torr;

DOI:10.1021/jo00076a059

Reference yield:

4-nitro-aniline (100-01-6,104810-17-5) + isobutyryl chloride (79-30-1) → N-(4-nitrophenyl)isobutyramide (7160-11-4)

Guidance literature:

In toluene; Heating;

DOI:10.1021/jo00076a059

Reference yield:

N-phenylisobutyramide (4406-41-1) → 2-methyl-N-(2-nitrophenyl)propanamide (6316-52-5) + N-(4-nitrophenyl)isobutyramide (7160-11-4)

Guidance literature:

With oxygen; Nitrogen dioxide; ozone; In chloroform; at 0 ℃; for 1.5h; Yield given. Yields of byproduct given;

upstream raw materials:

ISOPROPYLAMIDE

nitrobenzene

4-nitro-aniline

isobutyryl chloride

Downstream raw materials:

(4-amino-phenyl)-carbamic acid isobutyl ester

C₁₆H₁₆N₂O₃

Refernces

• 1、 Suzuki, Hitomi,Tatsumi, Atsuo,Ishibashi, Taro,Mori, Tadashi. "Ozone-mediated Reaction of Anilides and Phenyl Esters with Nitrogen Dioxide: Enhanced Ortho-reactivity and Mechanistic Implications". . p. 339 - 344. Retrieved 2007/10/02.