4406-41-1

Basic information

• Product Name: 2-METHYL-N-PHENYL-PROPANAMIDE
• Synonyms: 2-METHYL-N-PHENYL-PROPANAMIDE;2-Methyl-N-phenylpropionamide;N-Phenyl-2-methylpropanamide;N-Phenyl-2-methylpropionamide;N-Phenylisobutyramide;PropanaMide, 2-Methyl-N-phenyl-
• CAS NO: 4406-41-1
• Molecular Formula: C₁₀H₁₃NO
• Molecular Weight: 163.2163
• Mol File: 4406-41-1.mol
• Article Data: 86

Chemical Properties

• Boiling Point: 317.8°Cat760mmHg
• Flash Point: 185.8°C
• Appearance: /
• Density: 1.046g/cm³
• Vapor Pressure: 0.000375mmHg at 25°C
• Refractive Index: 1.551
• CAS DataBase Reference: 2-METHYL-N-PHENYL-PROPANAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-METHYL-N-PHENYL-PROPANAMIDE(4406-41-1)
• EPA Substance Registry System: 2-METHYL-N-PHENYL-PROPANAMIDE(4406-41-1)

Safety Data

• Hazardous Substances Data: 4406-41-1(Hazardous Substances Data)

Usage

General Description

2-Methyl-N-phenyl-propanamide is a chemical compound used in the production of pharmaceuticals and other organic substances. It is a white to off-white crystalline solid with a molecular formula of C11H15NO. 2-METHYL-N-PHENYL-PROPANAMIDE is classified as an amide, which is a derivative of a carboxylic acid. Its primary use is as an intermediate in the synthesis of various pharmaceuticals, such as anti-inflammatory and analgesic drugs. Additionally, it can also be utilized as a precursor in the production of other organic compounds, such as dyes and pigments. However, it is important to handle and store this chemical with care, as it may present risks to human health and the environment if not properly managed.

InChI:InChI=1/C10H13NO/c1-8(2)10(12)11-9-6-4-3-5-7-9/h3-8H,1-2H3,(H,11,12)

Upstream product

• 14016-34-3 N-(2-methyl-1-propenylidene)aniline 
• 861356-33-4 3,3,7,7,10,10-hexamethyl-[1,5]dioxecane-2,4,6,8,10-pentaone 
• 62-53-3 aniline 
• 7113-66-8 methyl-2 N-phenyl propanethioamide 
• 459-64-3 4-methoxybenzenediazonium tetrafluoroborate 
• 369-57-3 benzenediazonium tetrafluoroborate 
• 459-44-9 4-methylbenzenediazonium tetrafluoroborate 
• 2322-45-4 2-bromo-2-methyl-N-phenylpropanamide 
• 68-12-2 N,N-dimethyl-formamide 
• 19820-59-8 benzoic isobutyric anhydride 
• 187737-37-7 propene 
• 78-82-0 Isobutyronitrile 
• 591-50-4 iodobenzene 
• 78-83-1 2-methyl-propan-1-ol 

Downstream Products

• 13182-64-4 2-Isopropyl-3H-quinazolin-4-one 
• 14016-34-3 N-(2-methyl-1-propenylidene)aniline 
• 5833-38-5 Isobutyryl-phenyl-carbamic acid isopropyl ester 
• 121190-24-7 (E)-2-butenyl N-phenyl-2-methylpropanimidate 
• 121190-25-8 3-methyl-2-butenyl N-phenyl-2-methylpropanimidate 
• 66418-07-3 5-isopropyl-1-phenyl-1H-tetrazole 
• 7113-66-8 methyl-2 N-phenyl propanethioamide 
• 2322-45-4 2-bromo-2-methyl-N-phenylpropanamide 
• 996-30-5 isobutyric acid sodium salt 
• 6316-52-5 2-methyl-N-(2-nitrophenyl)propanamide 
• 7160-11-4 N-(4-nitrophenyl)isobutyramide 
• 1309448-76-7 N-(2-(4-chlorobenzoyl)phenyl)isobutyramide 
• 588-47-6 N-isobutylaniline 
• 1978-68-3 N-(2-(trifluoromethyl)phenyl)isobutyramide 

Relevant articles and documents

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An Environmentally Benign, Catalyst-Free N?C Bond Cleavage/Formation of Primary, Secondary, and Tertiary Unactivated Amides

Herein, we report an operationally simple, cheap, and catalyst-free method for the transamidation of a diverse range of unactivated amides furnishing the desired products in excellent yields. This protocol is environmentally friendly and operates under extremely mild conditions without using any promoter or additives. Significantly, this strategy has been implied in the chemoselective synthesis of a pharmaceutical molecule, paracetamol, on a gram-scale with excellent yield. We anticipate that this universally applicable strategy will be of great interest in drug discovery, biochemistry, and organic synthesis.

Preparation method of amide

The invention relates to a preparation method of an amide, wherein, under the action of oxygen, the isothiocyanate and the aldehyde can react to form an amide, and the reaction temperature can be effectively increased only when not less than 110 °C. This process is also suitable for the reaction of isocyanates with aldehydes to produce amides. The preparation method is cheap in raw material, wide in substrate application range and free of metal catalysts in the reaction process. The initiator or other activator is green and economical, and can effectively reduce the cost.

Photocatalyzed Triplet Sensitization of Oximes Using Visible Light Provides a Route to Nonclassical Beckmann Rearrangement Products

Oximes are valuable synthetic intermediates for the preparation of a variety of functional groups. To date, the stereoselective synthesis of oximes remains a major challenge, as most current synthetic methods either provide mixtures of E and Z isomers or furnish the thermodynamically preferred E isomer. Herein we report a mild and general method to achieve Z isomers of aryl oximes by photoisomerization of oximes via visible-light-mediated energy transfer (EnT) catalysis. Facile access to (Z)-oximes provides opportunities to achieve regio- and chemoselectivity complementary to those of widely used transformations employing oxime starting materials. We show an enhanced one-pot protocol for photocatalyzed oxime isomerization and subsequent Beckmann rearrangement that enables novel reactivity with alkyl groups migrating preferentially over aryl groups, reversing the regioselectivity of the traditional Beckmann reaction. Chemodivergent N- or O- cyclizations of alkenyl oximes are also demonstrated, leading to nitrones or cyclic oxime ethers, respectively.