2322-45-4

Basic information

• Product Name: 2-bromo-2-methyl-N-phenylpropanamide
• Synonyms: 2-Bromo-2-methyl-N-phenylpropanamide; propanamide, 2-bromo-2-methyl-N-phenyl-
• CAS NO: 2322-45-4
• Molecular Formula: C₁₀H₁₂BrNO
• Molecular Weight: 242.1124
• Mol File: 2322-45-4.mol
• Article Data: 14

Chemical Properties

• Boiling Point: 356.2°C at 760 mmHg
• Flash Point: 169.3°C
• Density: 1.434g/cm³
• Vapor Pressure: 2.96E-05mmHg at 25°C
• Refractive Index: 1.596
• CAS DataBase Reference: 2-bromo-2-methyl-N-phenylpropanamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-bromo-2-methyl-N-phenylpropanamide(2322-45-4)
• EPA Substance Registry System: 2-bromo-2-methyl-N-phenylpropanamide(2322-45-4)

Safety Data

• Hazardous Substances Data: 2322-45-4(Hazardous Substances Data)

Upstream product

• 4406-41-1 N-phenylisobutyramide 
• 62-53-3 aniline 
• 21718-11-6 N-phenyl-S-(4-trifluoromethylphenyl) sulfonamide 
• 20469-89-0 2-bromo-2-methylpropionyl chloride 
• 20769-85-1 2-bromoisobutyric acid bromide 

Downstream Products

• 47002-22-2 2,2-dimethyl-N-phenyl-3-piperidin-1-yl-propionamide 
• 4406-41-1 N-phenylisobutyramide 
• 1611-83-2 2-methyl-N-phenylacrylamide 
• 110228-43-8 1',5,5-trimethyl-3-phenylpyrrolidine-5'-spiro-2-oxazolidin-4-one 
• 1197040-29-1 phenyl isocyanate 
• 110228-42-7 2,5,5-trimethyl-2-dimethylamino-3-phenyloxazolidin-4-one 
• 116275-14-0 3-anilino-2,2-dimethyl-3-oxo-propanoic acid phenylmethyl ester 
• 85576-90-5 1-(N-phenylcarbamoyl)-1-methylethyl 2-methylprop-2-enoate 
• 85576-91-6 N-(1-phenylcarbamoyl-1-methylethyl)methacrylanilide 
• 85576-89-2 1-phenylcarbamoyl-1-methylethyl 2-anilinoisobutyrate 
• 35844-04-3 α-nitroisobutyranilide 
• 20049-03-0 2-amino-2-methyl-N-phenyl-propanamide 

Relevant articles and documents

Visible-Light-Driven Aryl Migration and Cyclization of α-Azido Amides

This paper reports two new visible-light-promoted radical reactions of α-azido amides. By catalysis of [Ir(ppy)2(dtbbpy)]PF6 with i-Pr2NEt as the reducing agent, N-aryl α-azido tertiary amides were first converted to the corresponding aminyl radicals through reduction of the azido group; the aminyl radicals then underwent N-to-N aryl migration to give α-anilinyl-functionalized amides. α-Azido secondary amides, on the other hand, reacted with the solvent ethanol and i-Pr2NEt to afford the imidazolinone products.

SUBSTITUTED AMIDE DERIVATIVES HAVING MULTIMODAL ACTIVITY AGAINST PAIN

The present invention relates to substituted amide derivatives of formula (I) having dual pharmacological activity towards both the sigma (σ) receptor, and the p-opioid receptor, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy, in particular for the treatment of pain.

Copper-Salt-Promoted Carbocyclization Reactions of α-Bromo- N -arylacylamides

A mild and convenient synthetic method for oxindoles and α-arylacylamides bearing an all carbon quaternary stereocenter from the readily available α-bromo-N-arylacylamides has been developed. This Cu(acac)2/Phen-promoted radical cyclization rea