20469-89-0

Basic information

• Product Name: 2-Bromoisobutyrylchloride
• Synonyms: 2-broMo-2-Methyl propionyl chloride;Propanoyl chloride,2-broMo-2-Methyl;α-broMoisobutyric acid chloride;2-Bromo-2-methylpropanoyl chloride;alpha-Bromoisobutyryl chloride
• CAS NO: 20469-89-0
• Molecular Formula: C₄H₆BrClO
• Molecular Weight: 185.45
• EINECS: 1312995-182-4
• Mol File: 20469-89-0.mol
• Article Data: 13

Chemical Properties

• Boiling Point: 60-75℃ (23 Torr)
• Flash Point: 44.1±19.8℃
• Appearance: /
• Density: 1.594±0.06 g/cm3 (20℃ 760 Torr)
• CAS DataBase Reference: 2-Bromoisobutyrylchloride(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Bromoisobutyrylchloride(20469-89-0)
• EPA Substance Registry System: 2-Bromoisobutyrylchloride(20469-89-0)

Safety Data

• Hazardous Substances Data: 20469-89-0(Hazardous Substances Data)

Usage

Description

2-Bromoisobutyrylchloride, also known as 2-Bromo-2-methylpropanoyl Chloride, is an organic compound with the chemical formula C4H6BrClO. It is a derivative of isobutyric acid, featuring a bromine atom and a chlorine atom attached to the carbon chain. 2-Bromoisobutyrylchloride is known for its reactivity and is commonly used in the synthesis of various chemical products.

Uses

Used in Photochemistry:
2-Bromoisobutyrylchloride is used as a reactant in the synthesis and process optimization of photoinitiators, specifically in the study of photoinitiator MMMP. Its reactivity and functional groups make it a valuable component in the development of new photoinitiators, which are crucial for various applications in the field of photochemistry, such as in the production of polymers and coatings.
Used in Pharmaceutical Industry:
Although not explicitly mentioned in the provided materials, 2-Bromoisobutyrylchloride can also be used in the pharmaceutical industry as an intermediate for the synthesis of various drugs and pharmaceutical compounds. Its unique structure and reactivity allow for the creation of new molecules with potential therapeutic applications.
Used in Chemical Synthesis:
2-Bromoisobutyrylchloride can be employed as a building block in the synthesis of various organic compounds, including specialty chemicals, agrochemicals, and other industrial products. Its bromine and chlorine atoms can be used for further functionalization and modification, making it a versatile starting material in organic chemistry.

Upstream product

• 79-30-1 isobutyryl chloride 
• 2052-01-9 2-bromo-2-methylpropionic acid 

Downstream Products

• 100976-99-6 4-(α-bromo-isobutyryl)-1,5-dimethyl-2-phenyl-1,2-dihydro-pyrazol-3-one 
• 69959-88-2 N,2-dimethyl-2-bromopropanamide 
• 60110-37-4 N-benzyl-α-bromoisobutyranilide 
• 129339-29-3 2-bromo-N-(2-hydroxyphenyl)-2-methylpropanamide 
• 88629-09-8 2-(1-bromo-1-methylethyl)-4-phenyl-quinazoline 
• 51368-55-9 isopropyl 2-bromo-2?methylpropanoate 
• 2322-45-4 2-bromo-2-methyl-N-phenylpropanamide 
• 23532-16-3 2-bromo-N-(2,6-dimethylphenyl)-2-methylpropanamide 
• 698394-60-4 2-bromo-1-(4-ethylphenyl)-2-methyl-propan-1-one 
• 29443-17-2 3-Bromo-1-phenyl-3-methyl-butanon 
• 2322-46-5 2-bromo-N-(4-bromophenyl)-2-methylpropanamide 
• 1390644-50-4 (R)-2-(3-(diisopropylamino)-1-phenylpropyl)-4-(hydroxymethyl)phenyl-2-bromo-2-methyl propanoate 
• 55106-47-3 2-bromo-2-methylpropanoyl cyanide 
• 869868-56-4 8-acetyl-5-benzyloxy-2,2-dimethyl-4H-benzo[1,4]oxazin-3-one 

Relevant articles and documents

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Method for synthesizing netarsudil intermediate

The invention relates to a method for synthesizing a netarsudil intermediate that is 6-aminoisoquinoline. The method includes (1) dissolving 2-bromo-2-methylpropionic acid; (2) adding oxalyl chloride,and then reacting the mixture; (3) after the reaction is completed, pouring the reaction solution into aqueous ammonia, stirring the mixture, performing filtration and drying a product. The method utilizes conventional and easily available chemical materials, and has characteristics of mild reactions, a short route and a high yield.

Synthesis method for alectinib hydrochloride intermediate

The invention discloses a synthesis method for an alectinib hydrochloride intermediate. The synthesis method includes the following steps: 1) with 2-bromo-2-methylpropionic acid as an initial raw material, adding thionyl chloride to perform a chlorination reaction to obtain a compound (I); 2) adding ethylbenzene to the compound (I) and adding anhydrous aluminum trichloride as a catalyst to perform a substitution reaction to obtain a compound (II); 3) dissolving the compound (II) in an organic solvent, adding HC(OMe)3 and a catalyst ZnCl2, performing heat reflux until a rearrangement reaction is completely finished to obtain a compound (III); 4) dissolving the compound (III) in an organic solvent, adding iodine and iodic acid to perform a catalytic reaction to generate a compound (IV); and 5) under alkaline condition, hydrolyzing the compound (IV) to produce the target product, alectinib hydrochloride intermediate. The synthesis method is simple in operations, has high yield and is lower in cost.