1-PHENYL-1-HEXANOL

Base Information

• Chemical Name: 1-PHENYL-1-HEXANOL
• CAS No.: 4471-05-0
• Molecular Formula: C12H18O
• Molecular Weight: 178.274
• Hs Code.: 2906299090
• Mol file: 4471-05-0.mol

Synonyms:alpha-Pentylbenzyl Alcohol;

Chemical Property of 1-PHENYL-1-HEXANOL

Chemical Property:

• Vapor Pressure: 0.00699mmHg at 25°C
• Refractive Index: 1.51
• Boiling Point: 258.5 °C at 760 mmHg
• Flash Point: 117.5 °C
• PSA: 20.23000
• Density: 0.955 g/cm³
• LogP: 3.30030

Purity/Quality:

98%,99%, ^*data from raw suppliers

1-Phenyl-1-hexanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-PHENYL-1-HEXANOL

There total 113 articles about 1-PHENYL-1-HEXANOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

caprophenone (942-92-7) → 1-phenylhexan-1-ol (4471-05-0)

Guidance literature:

caprophenone; With zinc diacetate; In tetrahydrofuran; at 65 ℃; for 0.166667h;

With methyl-di(n-propoxy)silane; In tetrahydrofuran; at 65 ℃; for 12h;

With hydrogenchloride; water; at 0 ℃; for 1h;

DOI:10.1055/s-0028-1087663

Reference yield: 96.0%

caprophenone (942-92-7) → (S)-1-phenylhexanol (4471-05-0,65488-03-1,106623-83-0,138381-77-8)

Guidance literature:

With (mer-[(S,S)-1,5-dimethyl-2,4-bis(4-phenyl-1,3-oxazolin-2-yl)benzene^(1-)]Ru(CO)Cl)2(ZnCl₂); hydrogen; sodium methylate; (-)-(S)-1-Anthracen-9-ylethanol; In isopropyl alcohol; at 40 ℃; for 24h; under 22801.5 Torr; optical yield given as %ee; enantioselective reaction; Inert atmosphere; Autoclave;

DOI:10.1039/c1cc16057e

Reference yield: 91.0%

6-bromo-1-phenyl-1-hexanol + tribenzyltin hydride (10113-30-1) → 1-phenylhexan-1-ol (4471-05-0) + tribenzyltin bromide (19127-37-8)

Guidance literature:

With triethyl borane; In hexane; at 20 ℃; for 0.5h; Inert atmosphere;

DOI:10.1016/j.jorganchem.2012.11.007

upstream raw materials:

caprophenone

n-pentylmagnesium bromide

benzaldehyde

styrene oxide

Downstream raw materials:

1-phenylhex-1-ene

caprophenone

Palmitinsaeure-(1-phenyl-hexyl)-ester

(S)-1-phenylhexanol

Refernces

• 1、 Ibá?ez, Susana,Poyatos, Macarena,Peris, Eduardo. "A Ferrocenyl-Benzo-Fused Imidazolylidene Complex of Ruthenium as Redox-Switchable Catalyst for the Transfer Hydrogenation of Ketones and Imines". . p. 3790 - 3795. Retrieved 2016.
• 2、 Chang, Xiao-Yong,Chen, Ji-Jun,Gu, Qiang-Shuai,Jiang, Sheng-Peng,Li, Zhong-Liang,Liu, Lin,Liu, Xiao-Dong,Liu, Xin-Yuan,Su, Xiao-Long,Wang, Fu-Li,Yang, Chang-Jiang,Ye, Liu. "Copper-Catalyzed Enantioconvergent Cross-Coupling of Racemic Alkyl Bromides with Azole C(sp2)?H Bonds". supporting information. p. 380 - 384. Retrieved 2020/10/30.
• 3、 Dey, Shreyata,Ghosh, Prasenjit,Prakasham, A. P.,Ta, Sabyasachi. "One pot tandem dual CC and CO bond reductions in the β-alkylation of secondary alcohols with primary alcohols by ruthenium complexes of amido and picolyl functionalized N-heterocyclic carbenes". supporting information. p. 15640 - 15654. Retrieved 2021/11/30.