2-Cyclohexylpiperidine

Base Information

• Chemical Name: 2-Cyclohexylpiperidine
• CAS No.: 56528-77-9
• Molecular Formula: C11H21N
• Molecular Weight: 167.294
• European Community (EC) Number: 260-246-1
• DSSTox Substance ID: DTXSID90880671
• Nikkaji Number: J296.706E
• Mol file: 56528-77-9.mol

Synonyms:2-Cyclohexylpiperidine;56528-77-9;EINECS 260-246-1;6-azabicyclohexane;Piperidine, 2-cyclohexyl-;SCHEMBL11191748;DTXSID90880671;BBL020718;STK893408;AKOS005638670;EN300-1233882

Chemical Property of 2-Cyclohexylpiperidine

Chemical Property:

• Vapor Pressure: 0.0237mmHg at 25°C
• Refractive Index: 1.482
• Boiling Point: 248.8 °C at 760 mmHg
• PKA: 10.56±0.10(Predicted)
• Flash Point: 102.2 °C
• PSA: 12.03000
• Density: 0.916g/cm³
• LogP: 3.03760
• XLogP3: 3.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 167.167399674
• Heavy Atom Count: 12
• Complexity: 127

Purity/Quality:

95-99% ^*data from raw suppliers

2-cyclohexylpiperidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CCC(CC1)C2CCCCN2

Technology Process of 2-Cyclohexylpiperidine

There total 13 articles about 2-Cyclohexylpiperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

2-phenylpyridine (1008-89-5) → (+/-)-2-cyclohexyl-piperidine (56528-77-9)

Guidance literature:

With hydrogen; In tert-butyl alcohol; at 135 ℃; for 30h; Autoclave;

DOI:10.1021/acscatal.9b02193

Reference yield: 83.0%

2-phenylpyridine (1008-89-5) → (+/-)-2-cyclohexyl-piperidine (56528-77-9) + 2-phenylpiperidine (3466-80-6)

Guidance literature:

With potassium hydroxide; aluminum nickel; In methanol; for 148.3h; Title compound not separated from byproducts; Heating;

DOI:10.1021/jo00354a021

Reference yield: 32.0%

2-phenylpyridine (1008-89-5) → (+/-)-2-cyclohexyl-piperidine (56528-77-9) + 2-pyridylcyclohexane (15787-49-2) + 2-phenylpiperidine (3466-80-6)

Guidance literature:

With Cp*Rh(2-(2-pyridyl)phenyl)H; hydrogen; In neat (no solvent); at 100 ℃; for 48h; under 27361.8 Torr; Catalytic behavior; Glovebox;

DOI:10.1021/jacs.9b09540

upstream raw materials:

2-phenyl-pyridine; hydrochloride

piperidine

cyclohexane

2-phenylpyridine

Downstream raw materials:

1-(2-cyclohexyl-piperidin-1-yl)-butane-1,3-dione

C₁₁H₂₁N

1-(2-cyclohexylpiperidino)pentan-4-one hydrochloride

1-cyclohexylpiperidine

Refernces

• 1、 Kim, Sangmin,Loose, Florian,Bezdek, Máté J.,Wang, Xiaoping,Chirik, Paul J.. "Hydrogenation of N-Heteroarenes Using Rhodium Precatalysts: Reductive Elimination Leads to Formation of Multimetallic Clusters". . p. 17900 - 17908. Retrieved 2019/11/19.
• 2、 Dwivedi, Ambikesh Dhar,Rai, Rohit Kumar,Gupta, Kavita,Singh, Sanjay Kumar. "Catalytic Hydrogenation of Arenes in Water Over In Situ Generated Ruthenium Nanoparticles Immobilized on Carbon". . p. 1930 - 1938. Retrieved 2017/06/13.