2-Phenylpiperidine

Base Information

• Chemical Name: 2-Phenylpiperidine
• CAS No.: 3466-80-6
• Molecular Formula: C11H15N
• Molecular Weight: 161.247
• Hs Code.: 29339900
• European Community (EC) Number: 222-422-6
• DSSTox Substance ID: DTXSID50956149
• Nikkaji Number: J216.136B
• Mol file: 3466-80-6.mol

Synonyms:2-phenylpiperidine

Chemical Property of 2-Phenylpiperidine

Chemical Property:

• Appearance/Colour: clear colorless liquid
• Vapor Pressure: 0.0147mmHg at 25°C
• Melting Point: 18 °C
• Refractive Index: 1.522
• Boiling Point: 257.253 °C at 760 mmHg
• PKA: 9.74±0.10(Predicted)
• Flash Point: 110.96 °C
• PSA: 12.03000
• Density: 0.967 g/cm³
• LogP: 2.83000
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• XLogP3: 2.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 161.120449483
• Heavy Atom Count: 12
• Complexity: 127

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-Phenylpiperidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 20/21/22
• Safety Statements: 23-24/25

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CCNC(C1)C2=CC=CC=C2

Technology Process of 2-Phenylpiperidine

There total 117 articles about 2-Phenylpiperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

2-phenyl-3,4,5,6-tetrahydropyridine (57050-07-4) → 2-phenylpiperidine (3466-80-6)

Guidance literature:

With sodium tetrahydroborate; In methanol; Inert atmosphere;

DOI:10.1021/ja211398b

Reference yield: 89.0%

C16H22N2O → 2-phenylpiperidine (3466-80-6)

Guidance literature:

With trifluoroacetic acid; hydrazine; In ethanol; at 120 ℃; for 1h;

DOI:10.1021/ja072577n

Reference yield: 83.0%

2-phenylpyridine (1008-89-5) → (+/-)-2-cyclohexyl-piperidine (56528-77-9) + 2-phenylpiperidine (3466-80-6)

Guidance literature:

With potassium hydroxide; aluminum nickel; In methanol; for 148.3h; Title compound not separated from byproducts; Heating;

DOI:10.1021/jo00354a021

upstream raw materials:

5-benzoyl-2-phenylpyridine

5-oxo-5-phenylpentanenitrile

2-phenyl-pyridine; hydrochloride

2,3,4,5-tetrahydropyridine

Downstream raw materials:

1-(tert-butyloxycarbonyl)4-(2-phenylpiperidin-1-yl)piperidine

cis/trans-1,3,4,6,7,11b-Hexahydro-7-hydroxy-7-phenyl-2H-benzoquinolizin-6-one

2-(2-phenylpiperidin-1-yl)-1H-benzoimidazole

R-trifluoroacetamide

Refernces

• 1、 W?glarz, Izabela,Michalak, Karol,Mlynarski, Jacek. "Zinc-Catalyzed Asymmetric Hydrosilylation of Cyclic Imines: Synthesis of Chiral 2-Aryl-Substituted Pyrrolidines as Pharmaceutical Building Blocks". supporting information. p. 1317 - 1321. Retrieved 2020/12/09.
• 2、 Clarke, Joshua J.,Maekawa, Yuuki,Nambo, Masakazu,Crudden, Cathleen M.. "Borenium-Catalyzed Reduction of Pyridines through the Combined Action of Hydrogen and Hydrosilane". supporting information. p. 6617 - 6621. Retrieved 2021/09/02.