3',5'-Diiodothyronine

Base Information

• Chemical Name: 3',5'-Diiodothyronine
• CAS No.: 60363-25-9
• Deprecated CAS: 93603-15-7
• Molecular Formula: C15H13 I2 N O4
• Molecular Weight: 525.082
• Hs Code.: 2922509090
• European Community (EC) Number: 262-198-7
• Nikkaji Number: J1.260.242A
• Mol file: 60363-25-9.mol

Synonyms:3',5'-diiodo-L-thyronine;3',5'-diiodothyronine;3',5'-diiodothyronine, (L)-isomer;3',5'-T2

Chemical Property of 3',5'-Diiodothyronine

Chemical Property:

• Vapor Pressure: 1.07E-10mmHg at 25°C
• Boiling Point: 497°C at 760 mmHg
• Flash Point: 254.4°C
• PSA: 92.78000
• Density: 2.095g/cm³
• LogP: 4.04840
• XLogP3: 1.1
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 5
• Exact Mass: 524.89340
• Heavy Atom Count: 22
• Complexity: 365

Purity/Quality:

98%Min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=CC=C1CC(C(=O)O)N)OC2=CC(=C(C(=C2)I)O)I

Technology Process of 3',5'-Diiodothyronine

There total 5 articles about 3',5'-Diiodothyronine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-(3,5-diiodo-4-methoxy-phenoxy)-benzaldehyde (860523-83-7) → 3',5'-diiodothyronine (60363-25-9)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium acetate; acetic acid anhydride / Erwaermen des danach isolierten Reaktionsprodukts mit wss.-aethanol. Natronlauge

2: phosphorus; phosphinic acid; aqueous hydriodic acid / anschl. Erhitzen mit wss. Bromwasserstoffsaeure

With phosphorus; hydrogen iodide; sodium acetate; hypophosphorous acid; acetic anhydride;

DOI:10.1577/1548-8659(2000)129<0194:GPSAOO>2.0.CO;2

Reference yield:

4-(3,5-diiodo-4-methoxy-phenoxy)-benzonitrile (855290-86-7) → 3',5'-diiodothyronine (60363-25-9)

Guidance literature:

Multi-step reaction with 3 steps

1: chloroform; SnCl₂; HCl / Reagens 4: Aether, Erhitzen des Reaktionsprodukts mit wss.HCl

2: sodium acetate; acetic acid anhydride / Erwaermen des danach isolierten Reaktionsprodukts mit wss.-aethanol. Natronlauge

3: phosphorus; phosphinic acid; aqueous hydriodic acid / anschl. Erhitzen mit wss. Bromwasserstoffsaeure

With hydrogenchloride; phosphorus; chloroform; hydrogen iodide; sodium acetate; hypophosphorous acid; acetic anhydride; tin(ll) chloride;

DOI:10.1577/1548-8659(2000)129<0194:GPSAOO>2.0.CO;2

Reference yield:

4-(3,5-diiodo-4-methoxy-phenoxy)-aniline; hydrochloride → 3',5'-diiodothyronine (60363-25-9)

Guidance literature:

Multi-step reaction with 4 steps

1: acetic acid; copper (II)-sulfate; water

2: chloroform; SnCl₂; HCl / Reagens 4: Aether, Erhitzen des Reaktionsprodukts mit wss.HCl

3: sodium acetate; acetic acid anhydride / Erwaermen des danach isolierten Reaktionsprodukts mit wss.-aethanol. Natronlauge

4: phosphorus; phosphinic acid; aqueous hydriodic acid / anschl. Erhitzen mit wss. Bromwasserstoffsaeure

With hydrogenchloride; phosphorus; chloroform; water; hydrogen iodide; sodium acetate; hypophosphorous acid; acetic anhydride; copper(II) sulfate; acetic acid; tin(ll) chloride;

DOI:10.1577/1548-8659(2000)129<0194:GPSAOO>2.0.CO;2

upstream raw materials:

acetic acid

4-(3,5-diiodo-4-methoxy-phenoxy)-benzaldehyde

4-(3,5-diiodo-4-methoxy-phenoxy)-benzonitrile