5-Hydroxy-2-methyl-benzoic acid

Base Information

• Chemical Name: 5-Hydroxy-2-methyl-benzoic acid
• CAS No.: 578-22-3
• Molecular Formula: C8H8O3
• Molecular Weight: 152.15
• Hs Code.: 2918290000
• Mol file: 578-22-3.mol

Synonyms:5,2-Cresoticacid (8CI);5-Hydroxy-2-methylbenzoic acid;NSC 36283;NSC 96583;

Chemical Property of 5-Hydroxy-2-methyl-benzoic acid

Chemical Property:

• Vapor Pressure: 2.63E-05mmHg at 25°C
• Melting Point: 182-187 °C
• Refractive Index: 1.599
• Boiling Point: 343.8 °C at 760 mmHg
• PKA: 3.78±0.25(Predicted)
• Flash Point: 175.9 °C
• PSA: 57.53000
• Density: 1.304 g/cm³
• LogP: 1.39880
• Storage Temp.: 2-8°C
• Water Solubility.: Slightly soluble in water.

Purity/Quality:

99% ^*data from raw suppliers

5-Hydroxy-2-methylbenzoic acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22-37/38-41
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 5-Hydroxy-2-methylbenzoic acid is used as a pharmaceutical intermediate.

Technology Process of 5-Hydroxy-2-methyl-benzoic acid

There total 27 articles about 5-Hydroxy-2-methyl-benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

methyl 3-hydroxy-6-methylbenzoate (73505-48-3) → 2-methyl-5-hydroxybenzoic acid (578-22-3)

Guidance literature:

With sodium hydroxide; In methanol; water; at 45 ℃; for 4h;

Reference yield: 74.0%

5-iodo-2-methylbenzoic?acid (54811-38-0) → 2-methyl-5-hydroxybenzoic acid (578-22-3)

Guidance literature:

With copper(I) oxide; 1D-1-O-Methyl-muco-inostol; sodium hydroxide; In water; at 100 ℃; for 6h;

Reference yield: 62.7%

5-amino-2-methylbenzoic acid (2840-04-2) → 2-methyl-5-hydroxybenzoic acid (578-22-3)

Guidance literature:

5-amino-2-methylbenzoic acid; With sulfuric acid; sodium nitrite; In water; at 0 ℃; for 0.5h;

In water; for 0.5h; Reflux;

DOI:10.1021/jm401276h

upstream raw materials:

6-amino-4-hydroxy-2-naphthalenesulfonic acid

2-naphthol-6,8-disulfonic acid

methyl 2-methyl-5-bromobenzoate

5-bromo-2-methylbenzoic acid

Downstream raw materials:

methyl 5-methoxy-2-methyl-benzoate

5-methoxy-o-toluic acid

5-(4-fluorophenoxy)-2-methyl-benzoic acid methyl ester

5-(4-fluorophenoxy)-2-methylbenzoic acid

Refernces

• 1、 -. "Application of quebrachitol in hydrolysis reaction of copper-catalyzed aryl halide". Paragraph 0084-0086. . Retrieved 2019/07/16.
• 2、 Baur, Benjamin,Storch, Kirsten,Martz, Kathrin E.,Goettert, Marcia I.,Richters, André,Rauh, Daniel,Laufer, Stefan A.. "Metabolically stable dibenzo[ b, e ]oxepin-11(6 H)-ones as highly selective p38 MAP kinase inhibitors: Optimizing anti-cytokine activity in human whole blood". supporting information. p. 8561 - 8578. Retrieved 2013/12/04.