METHYL-5-METHOXY-2-METHYLBENZOATE

Base Information

• Chemical Name: METHYL-5-METHOXY-2-METHYLBENZOATE
• CAS No.: 73505-48-3
• Molecular Formula: C9H10O3
• Molecular Weight: 166.177
• Hs Code.: 2918290000
• Mol file: 73505-48-3.mol

Synonyms:5,2-Cresoticacid, methyl ester (6CI);5-Hydroxy-2-methylbenzoic acid methyl ester;Methyl3-hydroxy-6-methylbenzoate;Methyl 5-hydroxy-2-methylbenzoate;methyl 5-hydroxy-2-methylbenzoate;benzoic acid, 5-hydroxy-2-methyl-, methyl ester;

Chemical Property of METHYL-5-METHOXY-2-METHYLBENZOATE

Chemical Property:

• Vapor Pressure: 0.001mmHg at 25°C
• Melting Point: 75-76 °C(Solv: ethyl acetate (141-78-6); ligroine (8032-32-4))
• Refractive Index: 1.542
• Boiling Point: 287.856 °C at 760 mmHg
• PKA: 9.45±0.18(Predicted)
• Flash Point: 124.994 °C
• PSA: 46.53000
• Density: 1.17 g/cm³
• LogP: 1.48720
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

98%,99%, ^*data from raw suppliers

Methyl5-hydroxy-2-methylbenzoate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of METHYL-5-METHOXY-2-METHYLBENZOATE

There total 12 articles about METHYL-5-METHOXY-2-METHYLBENZOATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

methanol (67-56-1) + 2-methyl-5-hydroxybenzoic acid (578-22-3) → methyl 3-hydroxy-6-methylbenzoate (73505-48-3)

Guidance literature:

With thionyl chloride; for 5h; Reflux;

Reference yield: 91.0%

2-methyl-5-hydroxybenzoic acid (578-22-3) + acetyl chloride (75-36-5) → methyl 3-hydroxy-6-methylbenzoate (73505-48-3)

Guidance literature:

In methanol; at 80 ℃; for 2h;

Reference yield: 91.0%

1-Methyl-4-oxo-2-trimethylsilanyl-cyclohexa-2,5-dienecarboxylic acid methyl ester (177853-25-7) → methyl 3-hydroxy-6-methylbenzoate (73505-48-3)

Guidance literature:

In trifluoroacetic acid; for 168h; Ambient temperature;

DOI:10.1021/jo952240g

upstream raw materials:

diazomethane

1-methyl-4-oxocyclohexa-2,5-dienecarboxylic acid methyl ester

methyl 5-amino-2-methylbenzoate

1-Methyl-4-oxo-2-trimethylsilanyl-cyclohexa-2,5-dienecarboxylic acid methyl ester

Downstream raw materials:

methyl 5-ethoxy-2-methylbenzoate

methyl 2-methyl-5-(naphth-2-ylmethoxy)benzoate

methyl 5-(2-chloro-4-nitrophenoxy)-2-methylbenzoate

methyl 2-methyl-5-(trifluoromethylsulfonyloxy)benzoate

Refernces

• 1、 -. "COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF ENHANCER OF ZESTE HOMOLOG 2 POLYPEPTIDE". Paragraph 1151-1154. . Retrieved 2018/07/15.
• 2、 -. "PHENYL AMINO PIPERIDINE mTORC INHIBITORS AND USES THEREOF". Paragraph 0385-0386. . Retrieved 2018/05/24.