4-Methoxy-4'-methylbenzophenone

Base Information

• Chemical Name: 4-Methoxy-4'-methylbenzophenone
• CAS No.: 23886-71-7
• Molecular Formula: C15H14 O2
• Molecular Weight: 226.275
• Hs Code.: 2914509090
• European Community (EC) Number: 839-795-1
• NSC Number: 163357
• DSSTox Substance ID: DTXSID50178586
• Nikkaji Number: J39.689C
• Wikidata: Q83049038
• Mol file: 23886-71-7.mol

Synonyms:23886-71-7;4-Methoxy-4'-methylbenzophenone;(4-Methoxyphenyl)(p-tolyl)methanone;(4-methoxyphenyl)(4-methylphenyl)methanone;(4-methoxyphenyl)-(4-methylphenyl)methanone;BENZOPHENONE, 4-METHOXY-4'-METHYL-;NSC 163357;BRN 2049977;MFCD00025812;NSC163357;(4-Methoxy-phenyl)-p-tolyl-methanone;SCHEMBL758577;4-methyl-4'methoxybenzophenone;4-methyl-4'-methoxybenzophenone;DTXSID50178586;HMS1607H06;STK285988;4-METHOXY-4-METHYLBENZOPHENONE;AKOS001482630;Benzophenone, 4-methoxy-4/'-methyl-;NSC-163357;Benzophenone, 4-methoxy-4//'-methyl-;4-methoxyphenyl-4-methylphenyl methanone;NCGC00338263-01;LS-38938;CS-0251178;FT-0638367;EN300-53905;AB01331605-02;AK-918/40897229;SR-01000392949;SR-01000392949-1;Z276846040

Chemical Property of 4-Methoxy-4'-methylbenzophenone

Chemical Property:

• Vapor Pressure: 8.06E-06mmHg at 25°C
• Melting Point: 92 °C
• Boiling Point: 374.9 °C at 760 mmHg
• Flash Point: 169.8 °C
• PSA: 26.30000
• Density: 1.088 g/cm³
• LogP: 3.23460
• Storage Temp.: 2-8°C
• XLogP3: 4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 226.099379685
• Heavy Atom Count: 17
• Complexity: 246

Purity/Quality:

99.0% ^*data from raw suppliers

(4-Methoxyphenyl)(4-methylphenyl)methanone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC=C(C=C1)C(=O)C2=CC=C(C=C2)OC

Technology Process of 4-Methoxy-4'-methylbenzophenone

There total 106 articles about 4-Methoxy-4'-methylbenzophenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

4-methyl-benzoyl chloride (874-60-2) + methoxybenzene (100-66-3) → 4-methoxy-4'-methylbenzophenone (23886-71-7)

Guidance literature:

With copper(II) ferrite; In neat (no solvent); at 35 - 38 ℃; for 18h;

DOI:10.1016/j.tetlet.2013.01.081

Reference yield: 95.0%

N-(3,5-bis(trifluoromethyl)phenyl)-4-methoxy-Ntosylbenzamide + di(p-tolyl)borinic acid (66117-64-4) → 4-methoxy-4'-methylbenzophenone (23886-71-7)

Guidance literature:

With (bis(tricyclohexyl)phosphine)palladium(II) dichloride; potassium carbonate; tricyclohexylphosphine; In 1,4-dioxane; at 110 ℃; for 6h; Inert atmosphere; Schlenk technique;

DOI:10.1016/j.jorganchem.2015.07.009

Reference yield: 95.0%

N-methyl-N-tosyl-p-methoxybenzamide (1445317-61-2) + di(p-tolyl)borinic acid (66117-64-4) → 4-methoxy-4'-methylbenzophenone (23886-71-7)

Guidance literature:

With [1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene](3-chloropyridyl)palladium(ll) dichloride; potassium carbonate; In tetrahydrofuran; at 65 ℃; for 12h; Inert atmosphere; Schlenk technique;

DOI:10.1016/j.tetlet.2018.05.003

upstream raw materials:

4-methoxy-benzoyl chloride

toluene

2,2,2-trifluoroethanol

(E)-2-anisyl-1,2-ditolyl<2-13C>vinyl bromide

Downstream raw materials:

Biphenyl-2-yl-(4-methoxy-phenyl)-p-tolyl-methanol

(E)-3-(4-Methoxy-phenyl)-3-p-tolyl-acrylic acid ethyl ester

1-(4-methoxyphenyl)-1-(4-methylphenyl)-4-methyl-4-(tetrahydropyran-2-yloxy)-pent-2-yn-1-ol

4-methoxy-4’-carboxybenzophenone

Refernces

• 1、 Zhang, Yilan,Yue, Xiaoguang,Liang, Chenfeng,Zhao, Jianming,Yu, Wenbo,Zhang, Pengfei. "Photo-induced oxidative cleavage of C-C double bonds of olefins in water". supporting information. . Retrieved 2021/08/27.
• 2、 Cavallo, Luigi,Nolan, Steven P.,Poater, Albert,Szostak, Michal,Yang, Shiyi,Zhou, Tongliang. "Suzuki-Miyaura cross-coupling of esters by selective O-C(O) cleavage mediated by air- And moisture-stable [Pd(NHC)(μ-Cl)Cl]2precatalysts: Catalyst evaluation and mechanism". . p. 3189 - 3197. Retrieved 2021/05/25.