1445317-61-2

Basic information

• Product Name: N-methyl-N-tosyl-p-methoxybenzamide
• Synonyms: N-methyl-N-tosyl-p-methoxybenzamide
• CAS NO: 1445317-61-2
• Molecular Weight: 319.381
• Mol File: 1445317-61-2.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: N-methyl-N-tosyl-p-methoxybenzamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-methyl-N-tosyl-p-methoxybenzamide(1445317-61-2)
• EPA Substance Registry System: N-methyl-N-tosyl-p-methoxybenzamide(1445317-61-2)

Safety Data

• Hazardous Substances Data: 1445317-61-2(Hazardous Substances Data)

Upstream product

• 100-07-2 4-methoxy-benzoyl chloride 
• 640-61-9 N-methyl-p-toluenesulfonylamide 
• 98-59-9 p-toluenesulfonyl chloride 
• 100-09-4 4-methoxybenzoic acid 

Downstream Products

• 1445315-84-3 methyl 3-(N-methyl-N-tosylamino)-2,2-dimethyl-3-(p-methoxyphenyl)propionate 
• 1023-17-2 4-methoxyphenyl benzyl ketone 
• 23886-71-7 4-methoxy-4'-methylbenzophenone 
• 57700-94-4 N-(p-methoxybenzoyl)piperidine 
• 62170-25-6 1-(4-methoxyphenyl)octan-1-one 
• 121-98-2 methyl 4-methoxybenzoate 
• 121-97-1 4-Methoxypropiophenone 
• 6946-35-6 butyl 4-methoxybenzoate 
• 1671-76-7 p-Methoxyvalerophenon 

Relevant articles and documents

Catalyst-Free, Metal-Free, and Chemoselective Transamidation of Activated Secondary Amides

A simple protocol, which is catalyst-free, metal-free, and chemoselective, for transamidation of activated secondary amides in ethanol as solvent under mild conditions is reported. A wide range of amines, amino acids, amino alcohols, and the substituents, which are problematic in catalyzed transamidation, are tolerated in this methodology. The transamidation reaction was successfully extended to water as the medium as well. The present methodology appears to be better than the other catalyzed transamidations reported recently.

Highly efficient synthesis of aryl ketones by PEPPSI-palladium catalyzed acylative Suzuki coupling of amides with diarylborinic acids

An improved acylative cross-coupling of various N-methyl-N-tosyl amides with diarylborinic acids for synthesis of aryl ketones is developed. In most cases, aryl ketones could be obtained in excellent yields by using 1 mol% 2,6-diisopropylphenylimidazolylidene and 3-chloropyridine co-supported palladium chloride as catalyst in the presence of 3 equiv. K2CO3 as base in refluxing THF. The readily prepared and cost-effective substrates, N-methyl-N-tosylamides and diarylborinic acids, and the commercially available catalyst system promise a practical and efficient access to aryl ketones.

Indium triiodide catalyzed reductive functionalization of amides via the single-stage treatment of hydrosilanes and organosilicon nucleophiles

The indium triiodide catalyzed single-stage cascade reaction of N-sulfonyl amides with hydrosilanes and two types of organosilicon nucleophiles such as silyl cyanide and silyl enolates selectively promoted deoxygenative functionalization to give α-cyanoamines and β-aminocarbonyl compounds, respectively.