57700-94-4

Basic information

• Product Name: Piperidino(4-methoxyphenyl) ketone
• Synonyms: 4-Methoxyphenyl(piperidino) ketone;4-Methoxyphenylpiperidino ketone;Piperidino(4-methoxyphenyl) ketone;(4-Methoxyphenyl)(piperidin-1-yl)Methanone
• CAS NO: 57700-94-4
• Molecular Formula: C₁₃H₁₇NO₂
• Molecular Weight: 219.2796
• Mol File: 57700-94-4.mol
• Article Data: 81

Chemical Properties

• Boiling Point: 373.7°Cat760mmHg
• Flash Point: 179.8°C
• Appearance: /
• Density: 1.104g/cm³
• Vapor Pressure: 8.81E-06mmHg at 25°C
• Refractive Index: 1.546
• CAS DataBase Reference: Piperidino(4-methoxyphenyl) ketone(CAS DataBase Reference)
• NIST Chemistry Reference: Piperidino(4-methoxyphenyl) ketone(57700-94-4)
• EPA Substance Registry System: Piperidino(4-methoxyphenyl) ketone(57700-94-4)

Safety Data

• Hazardous Substances Data: 57700-94-4(Hazardous Substances Data)

Usage

InChI:InChI=1/C13H17NO2/c1-16-12-7-5-11(6-8-12)13(15)14-9-3-2-4-10-14/h5-8H,2-4,9-10H2,1H3

Upstream product

• 696-62-8 para-iodoanisole 
• 116858-80-1 trimethylpiperidinocarbonylstannane 
• 116858-78-7 tributylpiperidinocarbonylstannane 
• 116858-83-4 triphenylpiperidinocarbonylstannane 
• 121767-17-7 C₁₂H₂₀N₂O₂Se₂ 
• 100-66-3 methoxybenzene 
• 110-89-4 piperidine 
• 100-07-2 4-methoxy-benzoyl chloride 
• 201230-82-2 carbon monoxide 
• 19501-58-7 4-methoxyphenylhydrazine hydrochloride 
• 2156-71-0 N-chloropiperidine 
• 213596-33-9 2-(4-methoxyphenyl)-5,5-dimethyl-1,3,2-dioxaborolane 
• 1445317-61-2 N-methyl-N-tosyl-p-methoxybenzamide 
• 56800-17-0 4-acetylphenyl 4-methoxybenzoate 

Downstream Products

• 105-13-5 4-Methoxybenzyl alcohol 
• 15190-14-4 2-(4-methoxyphenyl)-2-(piperidin-1-yl)acetonitrile 
• 50819-67-5 O-cholesteryl p-methoxythiobenzoate 
• 76335-54-1 1-[(2,3-dihydro-4H-1,4-benzodioxin)-2-ylmethyl]-4-(4-methoxy-benzoyl)piperidine 
• 6091-44-7 piperidine hydrochloride 
• 46441-11-6 1-(4-methoxy-benzyl)-piperidine 

Relevant articles and documents

Catalytic N-Acylation of Cyclic Amines by Arylglyoxylic Acids via Radical-Radical Cross-Coupling

A methodical mechanistic investigation allowed for the catalytic N-acylation of secondary cyclic amine counterparts by arylglyoxylic acids through radical-radical coupling. The reaction proceeds via a twofold SET-promoted Cu(I)/Cu(II) catalytic cycle under mild conditions. An analogous reaction variant allows for the N-acylation in a one-pot fashion directly starting from a secondary cyclic amine even in the presence of a second amine or hydroxy group.

Copper and N-Heterocyclic Carbene-Catalyzed Oxidative Amidation of Aldehydes with Amines

A one-pot two-step oxidative process has been developed for the tert-butyl hydroperoxide mediated transformation of aldehydes and amines into amides catalyzed by copper(I) iodide and an N-heterocyclic carbene. The process is additive-free and does not require the amine to be transformed into its hydrochloride salts. The method is simple and practicable, has a broad substrate scope, and uses economical, feasible, and abundant reagents.

Hydrosilylative reduction of primary amides to primary amines catalyzed by a terminal [Ni-OH] complex

A terminal [Ni-OH] complex1, supported by triflamide-functionalized NHC ligands, catalyzes the hydrosilylative reduction of a range of primary amides into primary amines in good to excellent yields under base-free conditions with key functional group tolerance. Catalyst1is also effective for the reduction of a variety of tertiary and secondary amides. In contrast to literature reports, the reactivity of1towards amide reduction follows an inverse trend,i.e., 1° amide > 3° amide > 2° amide. The reaction does not follow a usual dehydration pathway.