VARIAMINE BLUE B BASE

Base Information

• Chemical Name: VARIAMINE BLUE B BASE
• CAS No.: 101-64-4
• Molecular Formula: C13H14N2O
• Molecular Weight: 214.267
• Hs Code.: 2922299090
• European Community (EC) Number: 202-962-9
• UNII: X817863RG1
• DSSTox Substance ID: DTXSID1059236
• Nikkaji Number: J4.993J
• Wikidata: Q27293663
• ChEMBL ID: CHEMBL1565941
• Mol file: 101-64-4.mol

Synonyms:1,4-Benzenediamine,N-(4-methoxyphenyl)- (9CI);p-Phenylenediamine, N-(p-methoxyphenyl)-(6CI,7CI,8CI);4-(4-Methoxyphenylamino)aniline;4-Amino-4'-methoxydiphenylamine;4-Methoxy-4'-aminodiphenylamine;4'-Amino-4-methoxydiphenylamine;Diazol Blue O;Fast Blue VB Base;N-(4-Aminophenyl)-N-(4-methoxyphenyl)amine;N-(4-Aminophenyl)-p-anisidine;N-(4-Methoxyphenyl)-1,4-phenylenediamine;N-(p-Methoxyphenyl)-p-phenylenediamine;Naphthoelan Fast Blue BT;VariamineBlue B;Variamine Blue B Base;Variamine Blue base;Variamine Blue free base;p-Amino-p'-methoxydiphenylamine;

Chemical Property of VARIAMINE BLUE B BASE

Chemical Property:

• Vapor Pressure: 3.01E-06mmHg at 25°C
• Melting Point: 101°C
• Refractive Index: 1.653
• Boiling Point: 210 °C / 4mmHg
• Flash Point: 188.9°C
• PSA: 47.28000
• Density: 1.178g/cm³
• LogP: 3.67520
• XLogP3: 2.5
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 214.110613074
• Heavy Atom Count: 16
• Complexity: 194

Purity/Quality:

98% ^*data from raw suppliers

Variamine Blue B Base [Redox Indicator] >98.0%(T) ^*data from reagent suppliers

Safty Information:

• Statements: 20/21/22-36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=C(C=C1)NC2=CC=C(C=C2)N

Technology Process of VARIAMINE BLUE B BASE

There total 24 articles about VARIAMINE BLUE B BASE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

4-methoxy-N-(4-nitrosophenyl)aniline (7696-66-4) → Variamin Blau (101-64-4)

Guidance literature:

With titanium(III) chloride; In 1,4-dioxane; at 20 ℃; for 4h;

Reference yield: 66.0%

4-methoxy-aniline (104-94-9) + para-nitrophenyl bromide (586-78-7) → Variamin Blau (101-64-4)

Guidance literature:

4-methoxy-aniline; para-nitrophenyl bromide; With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium carbonate; XPhos; In isopropyl alcohol; at 110 ℃; for 24h; Inert atmosphere;

With potassium tert-butylate; bis(pinacol)diborane; In isopropyl alcohol; at 110 ℃; for 4h; chemoselective reaction; Inert atmosphere;

DOI:10.1016/j.tet.2018.12.035

Reference yield: 64.0%

4-chloro-N-(4-methoxyphenyl)aniline (41018-73-9) → Variamin Blau (101-64-4)

Guidance literature:

With bis[chloro(1,2,3-trihapto-allylbenzene)palladium(II)]; N-[2-(di(1-adamantyl)phosphino)phenyl]morpholine; ammonia; sodium t-butanolate; In 1,4-dioxane; at 110 ℃; for 18h; chemoselective reaction; Inert atmosphere;

DOI:10.1002/anie.201000526

upstream raw materials:

4-methoxy-N-(4-nitrosophenyl)aniline

4-methoxy-N-(4-nitrophenyl)aniline

N-(4-methoxyphenyl)-2,4-dinitrobenzenamine

5-amino-2-p-anisidino-benzenesulfonic acid

Downstream raw materials:

4-((4-methoxyphenyl)imino)cyclohexa-2,5-dien-1-one

Refernces

• 1、 Banthorpe,Cooper. "-". . p. 605. Retrieved 1968.
• 2、 Hirashima,Manabe. "-". . p. 259. Retrieved 1975.
• 3、 Liang, Xueting,Xu, Liang,Li, Cuihua,Jia, Xin,Wei, Yu. "One-pot propagation of (Hetero)Arylamines: Modular synthesis of diverse Amino-di(hetero)arylamines". . p. 721 - 731. Retrieved 2019/01/08.