4-chloro-N-(2-chloroethyl)benzamide

Base Information

• Chemical Name: 4-chloro-N-(2-chloroethyl)benzamide
• CAS No.: 51847-02-0
• Molecular Formula: C9H9Cl2NO
• Molecular Weight: 218.083
• Mol file: 51847-02-0.mol

Synonyms:

Chemical Property of 4-chloro-N-(2-chloroethyl)benzamide

Chemical Property:

• Vapor Pressure: 1.15E-05mmHg at 25°C
• Boiling Point: 369.9°C at 760 mmHg
• Flash Point: 177.5°C
• Density: 1.285g/cm³

Purity/Quality:

97% purity ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-chloro-N-(2-chloroethyl)benzamide

There total 7 articles about 4-chloro-N-(2-chloroethyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

4-chloro-N-(2-hydroxyethyl)-benzamide (7400-54-6) → 4-chloro-N-(2-chloroethyl)benzamide (51847-02-0)

Guidance literature:

With dmap; methanesulfonyl chloride; triethylamine; sodium chloride; In dichloromethane;

DOI:10.1016/j.tet.2014.06.001

Reference yield: 56.0%

2-chloroethanamine hydrochloride (870-24-6) + 4-chloro-benzoyl chloride (122-01-0) → 4-chloro-N-(2-chloroethyl)benzamide (51847-02-0)

Guidance literature:

With triethylamine; In dichloromethane; for 4h; Inert atmosphere;

DOI:10.1016/j.tet.2016.08.040

Reference yield: 35.0%

2-chloroethanamine hydrochloride (870-24-6) + para-Chlorobenzyl alcohol (873-76-7) → 4-chloro-N-(2-chloroethyl)benzamide (51847-02-0)

Guidance literature:

With tert.-butylhydroperoxide; iron(II) chloride tetrahydrate; calcium carbonate; In acetonitrile; at 80 ℃; for 4h;

DOI:10.1016/j.tet.2014.06.001

upstream raw materials:

4-chloro-N-(2-hydroxyethyl)-benzamide

2-chloroethanamine hydrochloride

4-chloro-benzoyl chloride

para-Chlorobenzyl alcohol

Downstream raw materials:

2-(4-chlorophenyl)-4,5-dihydro-1,3-oxazole

2-(4-chlorophenyl)-4,5-dihydro-1,3-thiazole

moclobemide

2-<2-(methylthio)-4-chlorophenyl>-2-oxazoline

Refernces

• 1、 Ellsworth, Alyssa A.,Magyar, Christina L.,Hubbell, Grace E.,Theisen, Chelsea C.,Holmes, Daniel,Mosey, R. Adam. "One-pot triflic anhydride-mediated synthesis of 1,2-disubstituted 2-imidazolines from N-(2-haloethyl)amides and amines". . p. 6380 - 6389. Retrieved 2016/09/23.
• 2、 Bantreil, Xavier,Kanfar, Nasreddine,Gehin, Nicolas,Golliard, Ethan,Ohlmann, Pauline,Martinez, Jean,Lamaty, Frédéric. "Iron-catalyzed benzamide formation. Application to the synthesis of moclobemide". . p. 5093 - 5099. Retrieved 2014/07/08.