5,7-Dihydroxy-3,3',4'-trimethoxyflavone

Base Information Edit

Chemical Name:5,7-Dihydroxy-3,3',4'-trimethoxyflavone
CAS No.:14549-84-9
Molecular Formula:C18H16 O7
Molecular Weight:344.321
Hs Code.:2914509090
NSC Number:168804
UNII:429X56Q8K5
DSSTox Substance ID:DTXSID20163080
Nikkaji Number:J374.260A
Wikidata:Q27258520
Metabolomics Workbench ID:75267
ChEMBL ID:CHEMBL350720
Mol file:14549-84-9.mol

Synonyms:14549-84-9;5,7-Dihydroxy-3,3',4'-trimethoxyflavone;Quercetin 3,3',4'-trimethyl ether;NSC-168804;4H-1-Benzopyran-4-one, 2-(3,4-dimethoxyphenyl)-5,7-dihydroxy-3-methoxy-;UNII-429X56Q8K5;2-(3,4-dimethoxyphenyl)-5,7-dihydroxy-3-methoxychromen-4-one;2-(3,4-Dimethoxy-phenyl)-5,7-dihydroxy-3-methoxy-chromen-4-one;429X56Q8K5;NSC 168804;5,7-Dihydroxy-3,3',4'-trimethoxy flavone;2-(3,4-Dimethoxyphenyl)-5,7-dihydroxy-3-methoxy-4H-1-benzopyran-4-one;NSC168804;5,3',4'-trimethoxy flavone;CHEMBL350720;SCHEMBL1252875;DTXSID20163080;TWMBFWDMMIGYEO-UHFFFAOYSA-N;2-(3,4-Dimethoxyphenyl)-5,7-dihydroxy-3-methoxy-4H-chromen-4-one;LMPK12112768;AKOS015963920;Quercetin 3,3/',4/'-trimethyl ether;2-(3,4-Dimethoxy-phenyl)-5,7-dihydroxy-;FLAVONE, 5,7-DIHYDROXY-3,3',4'-TRIMETHOXY-;Q27258520;2-(3,4-dimethoxyphenyl)-5,7-dihydroxy-3-methoxy-chromen-4-one;4H-1-Benzopyran-4-one,4-dimethoxyphenyl)-5,7-dihydroxy-3-methoxy-;5,7-dihydroxy-3-methoxy-2-(3,4-dimethoxyphenyl)-4H-chromen-4-one;4H-1-Benzopyran-4-one, 2-(3,4-dimethoxyphenyl)-5,7-dihydroxy-3-methoxy- (9CI)

Suppliers and Price of 5,7-Dihydroxy-3,3',4'-trimethoxyflavone

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of 5,7-Dihydroxy-3,3',4'-trimethoxyflavone Edit

Chemical Property:

Vapor Pressure:1.21E-13mmHg at 25°C
Boiling Point:571.1°Cat760mmHg
Flash Point:209.7°C
PSA：98.36000
Density:1.45g/cm³
LogP:2.89700
XLogP3:3.1
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:4
Exact Mass:344.08960285
Heavy Atom Count:25
Complexity:532

Purity/Quality:: 99%min ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=C(C=C(C=C1)C2=C(C(=O)C3=C(C=C(C=C3O2)O)O)OC)OC

Technology Process of 5,7-Dihydroxy-3,3',4'-trimethoxyflavone

There total 6 articles about 5,7-Dihydroxy-3,3',4'-trimethoxyflavone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 55317-02-7
2-methoxy-1-(2,4,6-trihydroxyphenyl)ethanone

: 24824-54-2
3,4-dimethoxybenzoic anhydride

: 14549-84-9
quercetin 3,3',4'-trimethyl ether

Guidance literature:: 2-methoxy-1-(2,4,6-trihydroxyphenyl)ethanone; 3,4-dimethoxybenzoic anhydride; With triethylamine; for 0.0833333h; Heating;

With potassium hydroxide; In methanol; for 0.333333h; sonication;
DOI:10.1021/jm040770b

Reference yield: 30.0%

: 117-39-5,74893-81-5
quercetol

: 74-88-4
methyl iodide

: 14549-84-9
quercetin 3,3',4'-trimethyl ether

: 3306-16-9
2-(3,4-dimethoxyphenyl)-3,7-dihydroxy-5-methoxy-4H-chromen-4-one

: 33708-72-4
ayanin

: 572-32-7
ayanin

: 1245-15-4
retusin

: 93876-67-6
3-hydroxy-2-(4-hydroxy-3-methoxyphenyl)-5,7-dimethoxy-4H-chromen-4-one

: 6068-80-0
2-(3,4-dimethoxyphenyl)-3,5-dihydroxy-7-methoxy-4H-chromen-4-one

Guidance literature:: With potassium carbonate; In acetone; at 20 ℃; for 3h;
DOI:10.1007/s00044-019-02412-7

Reference yield:

: 93-07-2
Veratric acid

: 14549-84-9
quercetin 3,3',4'-trimethyl ether

Guidance literature:: Multi-step reaction with 2 steps

1.1: 89 percent / methanesulfonyl chloride; Et₃N / tetrahydrofuran / 0 °C

2.1: Et₃N / 0.08 h / Heating

2.2: 74 percent / KOH / methanol / 0.33 h / sonication

With methanesulfonyl chloride; triethylamine; In tetrahydrofuran; 2.1: Allan-Robinson condensation;
DOI:10.1021/jm040770b