Isoarcapillin

Base Information

• Chemical Name: Isoarcapillin
• CAS No.: 85819-50-7
• Molecular Formula: C₁₈H₁₆O₈
• Molecular Weight: 360.32
• Mol file: 85819-50-7.mol

Synonyms:5,6-Dihydroxy-2-(4-hydroxy-2,5-dimethoxy-phenyl)-7-methoxy-chromen-4-one;isoarcapillin;

Chemical Property of Isoarcapillin

Chemical Property:

• Boiling Point: 667.1±55.0 °C(Predicted)
• PSA: 118.59000
• Density: 1.461±0.06 g/cm3(Predicted)
• LogP: 2.60260

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Isoarcapillin

There total 8 articles about Isoarcapillin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,5-dimethoxyphenol (18113-18-3) → 4',5,6-trihydroxy-2',5',7-trimethoxyflavone (85819-50-7)

Guidance literature:

Multi-step reaction with 6 steps

1: 3.5 g / K₂CO₃ / dimethylformamide

2: 3.4 g / POCl₃

3: 1.3 g

4: 0.23 g / 10percent H₃PO₄ / 2-methoxy-ethanol / 7 h / Heating

5: 0.12 g / DDQ

6: 40 mg / BCl₃

With phosphoric acid; boron trichloride; potassium carbonate; 2,3-dicyano-5,6-dichloro-p-benzoquinone; trichlorophosphate; In 2-methoxy-ethanol; N,N-dimethyl-formamide;

DOI:10.1248/cpb.32.4935

Reference yield:

3,6-dihydroxy-2,4-dimethoxyacetophenone (6962-57-8) → 4',5,6-trihydroxy-2',5',7-trimethoxyflavone (85819-50-7)

Guidance literature:

Multi-step reaction with 5 steps

1: 2.2 g / K₂CO₃ / dimethylformamide

2: 1.3 g

3: 0.23 g / 10percent H₃PO₄ / 2-methoxy-ethanol / 7 h / Heating

4: 0.12 g / DDQ

5: 40 mg / BCl₃

With phosphoric acid; boron trichloride; potassium carbonate; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In 2-methoxy-ethanol; N,N-dimethyl-formamide;

DOI:10.1248/cpb.32.4935

Reference yield:

1,4-dimethoxy-2-isopropyloxybenzene (86635-95-2) → 4',5,6-trihydroxy-2',5',7-trimethoxyflavone (85819-50-7)

Guidance literature:

Multi-step reaction with 5 steps

1: 3.4 g / POCl₃

2: 1.3 g

3: 0.23 g / 10percent H₃PO₄ / 2-methoxy-ethanol / 7 h / Heating

4: 0.12 g / DDQ

5: 40 mg / BCl₃

With phosphoric acid; boron trichloride; 2,3-dicyano-5,6-dichloro-p-benzoquinone; trichlorophosphate; In 2-methoxy-ethanol;

DOI:10.1248/cpb.32.4935

upstream raw materials:

4',6-diisopropyloxy-2',5,5',7-tetramethoxyflavone

2,5-dimethoxyphenol

3,6-dihydroxy-2,4-dimethoxyacetophenone

1,4-dimethoxy-2-isopropyloxybenzene

Refernces