Naphthalen-1-yl(piperidin-1-yl)methanone

Base Information

• Chemical Name: Naphthalen-1-yl(piperidin-1-yl)methanone
• CAS No.: 5454-14-8
• Molecular Formula: C16H17 N O
• Molecular Weight: 239.317
• NSC Number: 23066
• DSSTox Substance ID: DTXSID20969766
• Nikkaji Number: J965.279E
• Wikidata: Q82952802
• ChEMBL ID: CHEMBL1311752
• Mol file: 5454-14-8.mol

Synonyms:naphthalen-1-yl(piperidin-1-yl)methanone;5454-14-8;Naphthalen-1-yl-piperidin-1-yl-methanone;MLS001202928;SMR000518432;NSC23066;BAS 03228475;1-(1-naphthoyl)piperidine;1-naphthyl(piperidino)methanone;cid_229390;CHEMBL1311752;SCHEMBL11360223;BDBM73895;DTXSID20969766;HMS2817L23;NSC-23066;STK062422;1-(naphthalene-1-carbonyl)piperidine;1-naphthalenyl(1-piperidinyl)methanone;AKOS000622569;(Naphthalen-1-yl)(piperidin-1-yl)methanone;AG-205/04519053;SR-01000323765;SR-01000323765-1;Z31424465

Chemical Property of Naphthalen-1-yl(piperidin-1-yl)methanone

Chemical Property:

• Vapor Pressure: 3.11E-07mmHg at 25°C
• Boiling Point: 419.1°Cat760mmHg
• Flash Point: 198.6°C
• Density: 1.146g/cm³
• XLogP3: 3.9
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 239.131014166
• Heavy Atom Count: 18
• Complexity: 296

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CCN(CC1)C(=O)C2=CC=CC3=CC=CC=C32

Technology Process of Naphthalen-1-yl(piperidin-1-yl)methanone

There total 1 articles about Naphthalen-1-yl(piperidin-1-yl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

piperidine (110-89-4) + bis(1-naphthoyl) telluride (107469-89-6) → (naphthalen-1-yl)(piperidin-1-yl)methanone (5454-14-8) + para-bromoacetophenone (99-90-1)

Guidance literature:

With para-bromophenacyl bromide; In toluene; at 25 ℃; for 2h;

Reference yield: 89.0%

(naphthalen-1-yl)(piperidin-1-yl)methanone (5454-14-8) → 1-((piperidine-1-yl)methyl)naphthalene (6947-74-6)

Guidance literature:

With diethoxymethylane; zinc diacetate; In tetrahydrofuran; at 65 ℃; chemoselective reaction; Inert atmosphere;

DOI:10.1002/chem.201101143

upstream raw materials:

piperidine

bis(1-naphthoyl) telluride

Downstream raw materials:

1-((piperidine-1-yl)methyl)naphthalene

Refernces