2-(2-Hydroxyphenyl)acetamide

Base Information

• Chemical Name: 2-(2-Hydroxyphenyl)acetamide
• CAS No.: 22446-40-8
• Molecular Formula: C8H9 N O2
• Molecular Weight: 151.165
• Hs Code.: 2924299090
• European Community (EC) Number: 245-005-0
• DSSTox Substance ID: DTXSID40176990
• Nikkaji Number: J285.517H
• Wikidata: Q83047316
• Mol file: 22446-40-8.mol

Synonyms:2-(2-Hydroxyphenyl)acetamide;22446-40-8;EINECS 245-005-0;(hydroxyphenyl)acetamide;2-Hydroxyphenylacetamide;2-Hydroxybenzeneacetamide;2-Hydroxyphenyl acetamide;Oprea1_331695;SCHEMBL299227;DTXSID40176990;BBL003575;MFCD00025519;STK803129;AKOS005614004;VS-01367;CS-0308229;EN300-111736;Z1255356155

Chemical Property of 2-(2-Hydroxyphenyl)acetamide

Chemical Property:

• Vapor Pressure: 1.91E-06mmHg at 25°C
• Boiling Point: 384°Cat760mmHg
• Flash Point: 186°C
• PSA: 64.31000
• Density: 1.244g/cm³
• LogP: 1.56970
• Storage Temp.: -20°C Freezer, Under inert atmosphere
• Solubility.: DMSO (Slightly), Methanol (Very Slightly)
• XLogP3: 0.2
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 151.063328530
• Heavy Atom Count: 11
• Complexity: 147

Purity/Quality:

98%Min ^*data from raw suppliers

2-(2-Hydroxyphenyl)acetamide(~90%) ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C(=C1)CC(=O)N)O
• Uses: 2-(2-Hydroxyphenyl)acetamide can be prepared as androgen receptor inhibitors.

Technology Process of 2-(2-Hydroxyphenyl)acetamide

There total 5 articles about 2-(2-Hydroxyphenyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 15.0%

2-(2-methoxyphenyl)acetamide (33390-80-6) → 2-(2-hydroxyphenyl)acetamide (22446-40-8)

Guidance literature:

2-(2-methoxyphenyl)acetamide; With boron tribromide; In dichloromethane; at 0 - 20 ℃; for 1h;

With water; In dichloromethane; at 0 ℃; for 0.5h;

Reference yield:

→ 2-(2-hydroxyphenyl)acetamide (22446-40-8)

Guidance literature:

With ammonia;

Reference yield:

benzofuran-2(3H)-one (553-86-6) → 2-(2-hydroxyphenyl)acetamide (22446-40-8)

Guidance literature:

upstream raw materials:

benzofuran-2(3H)-one

sulfuric acid

2-(2-methoxyphenyl)acetamide

Downstream raw materials:

benzoyloxy-phenyl-acetic acid amide

2-[2-(2-Hydroxy-3-isopropylamino-propoxy)-phenyl]-acetamide

1-(2-carbamoylmethylphenoxy)-2,3-epoxypropane

tert-Butyl 2-[2-(aminocarbonylmethyl)phenoxy]-2-methylpropionate

Refernces

• 1、 -. "PPAR-activating compound and pharmaceutical composition comprising the compound". Page/Page column 34. . Retrieved 2008/06/13.