Technology Process of 17-Hydroxy-6-methylene-19-norpregn-4-ene-3,20-dione 17-acetate
There total 12 articles about 17-Hydroxy-6-methylene-19-norpregn-4-ene-3,20-dione 17-acetate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
sodium tetrahydroborate;
In
methanol;
at 20 ℃;
DOI:10.1021/op4003533
- Guidance literature:
-
Multi-step reaction with 7 steps
1: toluene-4-sulfonic acid; trimethyl orthoformate / dichloromethane / 2 h / 20 °C
2: sodium; ammonia / ethanol; water; tetrahydrofuran; tert-butyl alcohol / -60 °C / Inert atmosphere
3: hydrogenchloride / water; tetrahydrofuran / 0.33 h / 60 °C
4: toluene-4-sulfonic acid / 24 h / 20 °C
5: toluene-4-sulfonic acid / tetrahydrofuran / 24 h / 20 °C
6: trichlorophosphate / -10 °C
7: sodium tetrahydroborate / methanol / 20 °C
With
hydrogenchloride; sodium tetrahydroborate; ammonia; sodium; toluene-4-sulfonic acid; trichlorophosphate; trimethyl orthoformate;
In
tetrahydrofuran; methanol; ethanol; dichloromethane; water; tert-butyl alcohol;
2: |Birch Reduction / 6: |Vilsmeier-Haack Formylation;
DOI:10.1021/op4003533
- Guidance literature:
-
Multi-step reaction with 6 steps
1: sodium; ammonia / ethanol; water; tetrahydrofuran; tert-butyl alcohol / -60 °C / Inert atmosphere
2: hydrogenchloride / water; tetrahydrofuran / 0.33 h / 60 °C
3: toluene-4-sulfonic acid / 24 h / 20 °C
4: toluene-4-sulfonic acid / tetrahydrofuran / 24 h / 20 °C
5: trichlorophosphate / -10 °C
6: sodium tetrahydroborate / methanol / 20 °C
With
hydrogenchloride; sodium tetrahydroborate; ammonia; sodium; toluene-4-sulfonic acid; trichlorophosphate;
In
tetrahydrofuran; methanol; ethanol; water; tert-butyl alcohol;
1: |Birch Reduction / 5: |Vilsmeier-Haack Formylation;
DOI:10.1021/op4003533
