Technology Process of Nomegestrol acetate
There total 17 articles about Nomegestrol acetate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
[Rh(Binap)2]+[ClO4]-;
In
tetrahydrofuran;
at 80 ℃;
for 0.5h;
Solvent;
Temperature;
Sealed tube;
Inert atmosphere;
- Guidance literature:
-
With
chloranil;
In
1,4-dioxane;
at 90 - 95 ℃;
Solvent;
Temperature;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: toluene-4-sulfonic acid / tetrahydrofuran / 24 h / 20 °C
2: trichlorophosphate / -10 °C
3: sodium tetrahydroborate / methanol / 20 °C
4: 5%-palladium/activated carbon / ethanol; tetrahydrofuran / 0.75 h / Reflux
With
sodium tetrahydroborate; 5%-palladium/activated carbon; toluene-4-sulfonic acid; trichlorophosphate;
In
tetrahydrofuran; methanol; ethanol;
2: |Vilsmeier-Haack Formylation;
DOI:10.1021/op4003533
