Cyclohexylamidophosphoric acid diethyl ester

Base Information

• Chemical Name: Cyclohexylamidophosphoric acid diethyl ester
• CAS No.: 32405-88-2
• Molecular Formula: C10H22NO3P
• Molecular Weight: 235.263
• Hs Code.: 2931900090
• Mol file: 32405-88-2.mol

Synonyms:Cyclohexyl-amidophosphorsaeure-diaethylester;cyclohexyl-amidophosphoric acid diethyl ester;Diethyl cyclohexylaminophosphonate;diethylcyclohexylamidophosphate;diethyl cyclohexylphosphoramidate;diethyl cyclohexylphosphoroamidate;cyclohexyl-diethoxyphosphoryl-amine;Diethyl N-cyclohexylphosphoramidate;N-cyclohexyl diethyl phosphoramidate;

Chemical Property of Cyclohexylamidophosphoric acid diethyl ester

Chemical Property:

• Vapor Pressure: 0.00187mmHg at 25°C
• Boiling Point: 292.1°C at 760 mmHg
• Flash Point: 130.5°C
• PSA: 57.37000
• Density: 1.05g/cm³
• LogP: 3.48070

Purity/Quality:

99%min ^*data from raw suppliers

DIETHYL CYCLOHEXYLAMIDOPHOSPHATE AldrichCPR ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Cyclohexylamidophosphoric acid diethyl ester

There total 17 articles about Cyclohexylamidophosphoric acid diethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

cyclohexylamine (108-91-8,157973-60-9) + phosphonic acid diethyl ester (762-04-9) → diethyl cyclohexylphosphoramidate (32405-88-2)

Guidance literature:

With potassium carbonate; potassium hydrogencarbonate; tetrabutylammomium bromide; In tetrachloromethane; dichloromethane; at 15 - 20 ℃; for 2h;

DOI:10.1055/s-1984-30778

Reference yield: 92.0%

cyclohexylamine (108-91-8,157973-60-9) + diethyl chlorophosphate (814-49-3) → diethyl cyclohexylphosphoramidate (32405-88-2)

Guidance literature:

With aluminum oxide; at 20 ℃;

DOI:10.1080/00304940709356016

Reference yield: 86.0%

cyclohexylamine hydrochloride (4998-76-9) + phosphonic acid diethyl ester (762-04-9) → diethyl cyclohexylphosphoramidate (32405-88-2)

Guidance literature:

With potassium carbonate; potassium hydrogencarbonate; tetrabutylammomium bromide; In tetrachloromethane; dichloromethane; at 15 - 20 ℃; for 4h;

DOI:10.1055/s-1984-30778

upstream raw materials:

Tetraethyl pyrophosphate

cyclohexylamine

Anhydrid des Phosphorsaeure-diaethylesters mit Aethansulfonsaeure

phosphonic acid diethyl ester

Downstream raw materials:

cyclohexyl-(1,1,3,3-tetramethyl-butyl)-carbodiimide

3-cyclohexyl-2,4-dioxo-1,2,3,4-tetrahydroquinazoline

2-phenylbutyric acid N-cyclohexylamide

N-cyclohexyl-N'-phenylurea

Refernces

• 1、 Handoko,Benslimane, Zacharia,Arora, Paramjit S.. "Diselenide-Mediated Catalytic Functionalization of Hydrophosphoryl Compounds". supporting information. p. 5811 - 5816. Retrieved 2020/07/27.
• 2、 Kaboudin, Babak,Kazemi, Foad,Habibi, Fereshteh. "Fe3O4@MgO nanoparticles as an efficient recyclable catalyst for the synthesis of phosphoroamidates via the Atherton-Todd reaction Dedicated to Professor Tsutomu Yokomatsu from Tokyo University of Pharmacy and Life Sciences on the occasion of his 65th birthday". supporting information. p. 6364 - 6367. Retrieved 2015/11/16.