N-(biphenyl-2-yl)-2-methylpropanamide

Base Information

• Chemical Name: N-(biphenyl-2-yl)-2-methylpropanamide
• CAS No.: 17261-12-0
• Molecular Formula: C₁₆H₁₇NO
• Molecular Weight: 239.317
• Mol file: 17261-12-0.mol

Synonyms:Propionanilide,2-methyl-2'-phenyl- (6CI,8CI); N-(2-Biphenylyl)isobutyramide; NSC 144968

Chemical Property of N-(biphenyl-2-yl)-2-methylpropanamide

Chemical Property:

• Vapor Pressure: 2.06E-06mmHg at 25°C
• Boiling Point: 393.9°C at 760 mmHg
• Flash Point: 239°C
• Density: 1.081g/cm³

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-(biphenyl-2-yl)-2-methylpropanamide

There total 6 articles about N-(biphenyl-2-yl)-2-methylpropanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

iodobenzene (591-50-4) + N-phenylisobutyramide (4406-41-1) → N-([1,1'-biphenyl]-2-yl)isobutyramide (17261-12-0)

Guidance literature:

N-phenylisobutyramide; With silver hexafluoroantimonate; dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; silver trifluoroacetate; In 1,2-dichloro-ethane; for 0.0833333h; Sealed tube; Inert atmosphere;

iodobenzene; In 1,2-dichloro-ethane; at 120 ℃; for 24h; Sealed tube; Inert atmosphere;

DOI:10.1002/adsc.201400798

Reference yield: 55.0%

N-phenylisobutyramide (4406-41-1) + phenylboronic acid (98-80-6) → N-([1,1'-biphenyl]-2-yl)isobutyramide (17261-12-0)

Guidance literature:

With silver hexafluoroantimonate; (p-cymene)ruthenium(II) chloride; copper(II) bis(trifluoromethanesulfonate); silver(l) oxide; In N,N-dimethyl-formamide; at 110 ℃; for 20h; Inert atmosphere; Sealed tube;

DOI:10.1002/adsc.201400906

Reference yield:

N-phenylisobutyramide (4406-41-1) + Diphenyliodonium triflate (66003-76-7) → N-([1,1'-biphenyl]-2-yl)isobutyramide (17261-12-0) + C16H17NO

Guidance literature:

In 1,2-dichloro-ethane; at 70 ℃; for 22h; Overall yield = 38 %; Overall yield = 27.5 mg; regioselective reaction;

DOI:10.1055/s-0036-1589007

upstream raw materials:

2-phenylaniline

isobutyryl chloride

iodobenzene

N-phenylisobutyramide

Refernces

• 1、 -. "PROCESS FOR PREPARING BIPHENYLAMINES FROM ANILIDES BY RUTHENIUM CATALYSIS". Page/Page column 33-34. . Retrieved 2016/11/28.
• 2、 Haridharan, Radhakrishnan,Muralirajan, Krishnamoorthy,Cheng, Chien-Hong. "Rhodium(III)-catalyzed ortho-arylation of anilides with aryl halides". supporting information. p. 366 - 370. Retrieved 2015/03/05.