2,5,8,11,14-Pentaoxahexadecan-16-amine

Base Information

• Chemical Name: 2,5,8,11,14-Pentaoxahexadecan-16-amine
• CAS No.: 5498-83-9
• Molecular Formula: C18H12ClNO
• Molecular Weight: 251.323
• Hs Code.: 2921199090
• NSC Number: 165798
• Mol file: 5498-83-9.mol

Synonyms:m-PEG5-amine;5498-83-9;2,5,8,11,14-PENTAOXAHEXADECAN-16-AMINE;mPEG5-NH2;m-PEG5-NH2;2-[2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]ethoxy]ethanamine;NSC165798;SCHEMBL16546799;WGQYVGMCDPUCEJ-UHFFFAOYSA-N;MFCD27977523;BT-0155;NSC-165798;BP-22075;HY-140225;CS-0114797;2,5,8,11,14-pentaoxahexa-decan-16-amine;C70294;A870305

Chemical Property of 2,5,8,11,14-Pentaoxahexadecan-16-amine

Chemical Property:

• Vapor Pressure: 0.000244mmHg at 25°C
• Refractive Index: 1.444
• Boiling Point: 465.6 °C at 760 mmHg
• PKA: 8.74±0.10(Predicted)
• Flash Point: 235.4 °C
• PSA: 72.17000
• Density: 1.282 g/cm³
• LogP: 0.35820
• Storage Temp.: -20°C
• Solubility.: Soluble in Water, DMSO, DCM, DMF
• XLogP3: -1.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 14
• Exact Mass: 251.17327290
• Heavy Atom Count: 17
• Complexity: 137

Purity/Quality:

98%,99%, ^*data from raw suppliers

m-PEG5-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COCCOCCOCCOCCOCCN
• Description: m-PEG5-amine is a PEG linker containing an amino group with 5 PEG units. The amino group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The hydrophilic PEG spacer increases solubility in aqueous media.
• Uses: Applications may include: bioconjugation, drug delivery, PEG hydrogel, crosslinker, and surface functionalization

Technology Process of 2,5,8,11,14-Pentaoxahexadecan-16-amine

There total 7 articles about 2,5,8,11,14-Pentaoxahexadecan-16-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

→ 2,5,8,11,14-pentaoxahexadecane-16-amine (5498-83-9,80506-64-5,869718-87-6)

Guidance literature:

With phthalimide; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; toluene; at 20 ℃;

With hydrazine hydrate; In ethanol; Reflux;

Reference yield: 61.4%

C19H27NO7 → 2,5,8,11,14-pentaoxahexadecane-16-amine (5498-83-9,80506-64-5,869718-87-6)

Guidance literature:

With hydrazine hydrate; In tetrahydrofuran; ethanol; for 10h; Reflux;

Reference yield:

3,6,9,12,15-pentaoxahexadecanol (23778-52-1,95507-80-5) → 2,5,8,11,14-pentaoxahexadecane-16-amine (5498-83-9,80506-64-5,869718-87-6)

Guidance literature:

Multi-step reaction with 3 steps

1: pyridine / 0 °C

2: sodium azide / dimethylformamide / 12 h / 50 °C

3: 1.) PPh₃, 2.) H₂O / 1.) THF, RT, 12 h, 2.) RT, 12 h

With pyridine; sodium azide; water; triphenylphosphine; In N,N-dimethyl-formamide;

DOI:10.1021/ja00091a005

upstream raw materials:

16-azido-2,5,8,11,14-pentaoxahexadecane

3,6,9,12,15-pentaoxahexadecanol

3,6,9,12,15-pentaoxahexadecyl tosylate

2-(2-(2-methoxyethoxy)ethoxy)ethyl p-toluenesulfonate

Downstream raw materials:

C₁₉H₃₂N₂O₁₀

Refernces

• 1、 -. "Curcumin derivative and uses thereof". . . Retrieved 2019/08/01.
• 2、 Jain, Ahamindra,Huang, Shaw G.,Whitesides, George M.. "Lack of effect of the length of oligoglycine- and oligo(ethylene glycol)-derived para-substituents on the affinity of benzenesulfonamides for carbonic anhydrase II in solution". . p. 5057 - 5062. Retrieved 2007/10/02.