1,3-diphenyl-2-aminopropane

Base Information

• Chemical Name: 1,3-diphenyl-2-aminopropane
• CAS No.: 4275-43-8
• Molecular Formula: C15H17N
• Molecular Weight: 211.307
• Hs Code.: 2921499090
• Mol file: 4275-43-8.mol

Synonyms:2-Propanamine,1,3-diphenyl;3,3-diphenyl-1-propylamine;1-Benzyl-2-phenyl-ethylamine;1,3-Diphenyl-2-aminopropane;1,3-diphenylprop-2-ylamine;Dibenzylmethylamine;1-3-diphenyl-amino-2-propane;

Chemical Property of 1,3-diphenyl-2-aminopropane

Chemical Property:

• Vapor Pressure: 0.000151mmHg at 25°C
• Melting Point: 48-49 °C
• Boiling Point: 331.9°C at 760 mmHg
• PKA: 9.21±0.10(Predicted)
• Flash Point: 155.2°C
• PSA: 26.02000
• Density: 1.038±0.06 g/cm3(Predicted)
• LogP: 3.49940

Purity/Quality:

99% ^*data from raw suppliers

1,3-Diphenylpropan-2-amine 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1,3-diphenyl-2-aminopropane

There total 13 articles about 1,3-diphenyl-2-aminopropane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

1,3-diphenylpropan-2-one oxime (1788-31-4) → 1-benzyl-2-phenylethylamine (4275-43-8)

Guidance literature:

With sodium tetrahydroborate; titanium tetrachloride; In 1,2-dimethoxyethane; for 14h; Ambient temperature;

DOI:10.1055/s-1980-29174

Reference yield: 81.0%

1,3-Diphenylpropanone (102-04-5) → 1-benzyl-2-phenylethylamine (4275-43-8)

Guidance literature:

With nickel(II) tetrafluoroborate hexahydrate; ammonia; hydrogen; bis(2-diphenylphosphinoethyl)phenylphosphine; In 2,2,2-trifluoroethanol; at 120 ℃; for 24h; chemoselective reaction;

DOI:10.1039/d0sc01084g

Reference yield:

N-(1-benzyl-2-phenyl-ethyl)-4-nitroso-aniline (859964-05-9) → p-nitrosophenol (104-91-6) + 1-benzyl-2-phenylethylamine (4275-43-8)

Guidance literature:

DOI:10.1021/ja01226a031

upstream raw materials:

1,3-diphenylpropan-2-one oxime

2-benzyl-3-phenyl-propionyl chloride

2-benzyl-3-phenylpropanoic acid

N-(1-benzyl-2-phenyl-ethyl)-formamide

Downstream raw materials:

nicotinic acid-(1-benzyl-2-phenyl-ethylamide)

N,N'-bis-(1-benzyl-2-phenyl-ethyl)-urea

1-benzyl-2-phenyl-ethyl isocyanate

N-(α-benzylphenethyl)benzamide

Refernces

• 1、 Han, Hui,Zhang, Tao,Yang, Shang-Dong,Lan, Yu,Xia, Ji-Bao. "Palladium-Catalyzed Enantioselective C-H Aminocarbonylation: Synthesis of Chiral Isoquinolinones". supporting information. p. 1749 - 1754. Retrieved 2019/03/11.
• 2、 Eey, Stanley T.-C.,Lear, Martin J.. "Total synthesis of (-)-platensimycin by advancing oxocarbenium- and iminium-mediated catalytic methods". . p. 11556 - 11573. Retrieved 2015/01/16.