(R)-5,6-Dihydro-5-[(4-hydroxyphenyl)methyl]-2-naphthol

Base Information

• Chemical Name: (R)-5,6-Dihydro-5-[(4-hydroxyphenyl)methyl]-2-naphthol
• CAS No.: 50938-82-4
• Molecular Formula: C17H16O2
• Molecular Weight: 252.31
• Mol file: 50938-82-4.mol

Synonyms:

Chemical Property of (R)-5,6-Dihydro-5-[(4-hydroxyphenyl)methyl]-2-naphthol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-5,6-Dihydro-5-[(4-hydroxyphenyl)methyl]-2-naphthol

There total 22 articles about (R)-5,6-Dihydro-5-[(4-hydroxyphenyl)methyl]-2-naphthol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

(+/-)-di-O-methylsequirin D (79813-32-4) → (+/-)-sequirin D (79813-33-5,50938-82-4)

Guidance literature:

With pyridine hydrochloride; for 2h; Heating;

DOI:10.1039/P19810002662

Reference yield: 17.0%

7-hydroxy-4-p-hydroxybenzyl-1,2,3,4-tetrahydro-1-naphthol (79754-54-4) → (+/-)-sequirin D (79813-33-5,50938-82-4)

Guidance literature:

With trichlorophosphate; In pyridine; for 4h;

DOI:10.1039/P19810002662

Reference yield:

p-methoxy-α-p-methoxyphenylcinnamonitrile (6443-74-9) → (+/-)-sequirin D (79813-33-5,50938-82-4)

Guidance literature:

Multi-step reaction with 7 steps

1: 21 percent / dry hydrogen chloride / tin(II) chloride / diethyl ether / 6 h

2: 20 percent / piperidine / pyridine / 1.) steam-bath, 10 h, 2.) reflux, 4 h

3: 63 percent / aq. sodium hydroxide, nickel-aluminium alloy / 2 h / 80 °C

4: 84 percent / polyphosphoric acid / 1.5 h / 85 °C

5: 76 percent / 48percent hydrobromic acid / acetic acid / 6 h / Heating

6: 90 percent / sodium borohydride / ethanol

7: 17 percent / phosphorus oxychloride / pyridine / 4 h

With piperidine; hydrogenchloride; sodium hydroxide; sodium tetrahydroborate; PPA; nickel-aluminium alloy; hydrogen bromide; trichlorophosphate; tin(ll) chloride; In pyridine; diethyl ether; ethanol; acetic acid;

DOI:10.1039/P19810002662

upstream raw materials:

(+/-)-di-O-methylsequirin D

7-hydroxy-4-p-hydroxybenzyl-1,2,3,4-tetrahydro-1-naphthol

1,4-di(4-methoxyphenyl)ethanone

1, 2-bis(4-methoxyphenyl)prop-2-en-1-one

Refernces