(+/-)-di-O-methylsequirin D

Base Information

• Chemical Name: (+/-)-di-O-methylsequirin D
• CAS No.: 79813-32-4
• Molecular Formula: C₁₉H₂₀O₂
• Molecular Weight: 280.367
• Mol file: 79813-32-4.mol

Synonyms:(+/-)-di-O-methylsequirin D

Chemical Property of (+/-)-di-O-methylsequirin D

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (+/-)-di-O-methylsequirin D

There total 24 articles about (+/-)-di-O-methylsequirin D which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

7-methoxy-4-p-methoxybenzyl-1,2,3,4-tetrahydro-1-naphthol (79754-57-7) → (+/-)-di-O-methylsequirin D (79813-32-4)

Guidance literature:

With toluene-4-sulfonic acid; In benzene; for 12h; Heating;

DOI:10.1039/P19810002662

Reference yield:

1,4-di(4-methoxyphenyl)ethanone (120-44-5) → (+/-)-di-O-methylsequirin D (79813-32-4)

Guidance literature:

Multi-step reaction with 7 steps

1: 1.) magnesium / 1.) tetahydrofuran, 35 deg c,1 h, 2.) room temperature

2: 87 percent / hydrogen, sulphuric acid / 5 percent palladium-carbon / methanol

3: 99 percent / sulphuric acid / dioxane; H₂O / Ambient temperature

4: 80 percent / silver nitrate, sodium hydroxide / ethanol; H₂O / 4 h / Ambient temperature

5: 42 percent / hydrogen fluoride / 48 h / Ambient temperature

6: 83 percent / lithium aluminium hydride / diethyl ether / 2 h / Ambient temperature

7: 85 percent / toluene-p-sulphonic acid / toluene / 3 h / Heating

With sodium hydroxide; lithium aluminium tetrahydride; sulfuric acid; hydrogen fluoride; hydrogen; toluene-4-sulfonic acid; silver nitrate; magnesium; palladium on activated charcoal; In 1,4-dioxane; methanol; diethyl ether; ethanol; water; toluene;

Reference yield:

(E)-1,1-ethylenedioxy-4,5-bis-(p-methoxyphenyl)pent-4-ene (81574-79-0) → (+/-)-di-O-methylsequirin D (79813-32-4)

Guidance literature:

Multi-step reaction with 5 steps

1: hydrogen / 5percent palladium -carbon / methanol

2: 80 percent / silver nitrate, sodium hydroxide / ethanol; H₂O / 4 h / Ambient temperature

3: 42 percent / hydrogen fluoride / 48 h / Ambient temperature

4: 83 percent / lithium aluminium hydride / diethyl ether / 2 h / Ambient temperature

5: 85 percent / toluene-p-sulphonic acid / toluene / 3 h / Heating

With sodium hydroxide; lithium aluminium tetrahydride; hydrogen fluoride; hydrogen; toluene-4-sulfonic acid; silver nitrate; palladium -carbon; In methanol; diethyl ether; ethanol; water; toluene;

upstream raw materials:

7-methoxy-4-p-methoxybenzyl-1,2,3,4-tetrahydro-1-naphthol

1,4-di(4-methoxyphenyl)ethanone

7-methoxy-4-p-methoxybenzyl-3,4-dihydronaphthalen-1(2H)-one

4,5-bis-(p-methoxyphenyl)pentanoic acid

Downstream raw materials:

(+/-)-sequirin D

Refernces

• 1、 Reddy, M. Parameswara,Rao, G. S. Krishna. "Synthesis of 5-p-Hydroxybenzyl-5,6-dihydro-2-naphthol, (+/-)-Sequirin D". . p. 2662 - 2665. Retrieved 2007/10/02.