120-44-5

Basic information

• Product Name: DESOXYANISOIN
• Synonyms: A-(P-ANISYL)-P-METHOXYACETOPHENONE;DESOXYANISOIN;DEOXYANISOIN;4'-METHOXY-2-(P-METHOXYPHENYL)ACETOPHENONE;4'-METHOXY-2-(4-METHOXYPHENYL)ACETOPHENONE;4-METHOXYBENZYL 4-METHOXYPHENYL KETONE;1,2-BIS-(4-METHOXY-PHENYL)-ETHANONE;1,2-Bis(p-methoxyphenyl)ethanone
• CAS NO: 120-44-5
• Molecular Formula: C16H16O3
• Molecular Weight: 256.3
• EINECS: 204-396-8
• Product Categories: Aromatic Ketones (substituted)
• Mol File: 120-44-5.mol
• Article Data: 59

Chemical Properties

• Melting Point: 110-112 °C(lit.)
• Boiling Point: 339.54°C (rough estimate)
• Flash Point: 196.9 °C
• Appearance: white to slightly yellow crystals
• Density: 1.115
• Vapor Pressure: 4.07E-07mmHg at 25°C
• Refractive Index: 1.4500 (estimate)
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• Water Solubility: Sparingly soluble in water.
• BRN: 1536594
• CAS DataBase Reference: DESOXYANISOIN(CAS DataBase Reference)
• NIST Chemistry Reference: DESOXYANISOIN(120-44-5)
• EPA Substance Registry System: DESOXYANISOIN(120-44-5)

Safety Data

• Safety Statements: 24/25
• WGK Germany: 3
• Hazardous Substances Data: 120-44-5(Hazardous Substances Data)

Usage

Description

Desoxyanisoin is an organic compound that is characterized by its white to slightly yellow crystalline structure or crystalline powder. It is known for its ability to undergo specific chemical reactions, such as reacting with reagents like CCl4 and bromine to produce a-bromo-4,4'-dimethoxy-deoxybenzoin.

Uses

Used in Chemical Synthesis:
Desoxyanisoin is used as a chemical intermediate for the synthesis of various organic compounds. Its ability to react with specific reagents, such as CCl4 and bromine, makes it a valuable component in the production of a-bromo-4,4'-dimethoxy-deoxybenzoin and potentially other related compounds.
Used in Pharmaceutical Industry:
Desoxyanisoin may be utilized as a building block or intermediate in the development of pharmaceuticals, particularly those that require its unique chemical properties for drug synthesis or modification.
Used in Research and Development:
Due to its specific chemical properties and reactivity, Desoxyanisoin can be employed in research and development settings to study and understand the behavior of similar organic compounds, as well as to develop new methods for chemical synthesis and compound modification.
Used in Analytical Chemistry:
The distinct chemical properties of Desoxyanisoin make it suitable for use in analytical chemistry, where it can be employed as a reference compound or standard for the calibration of analytical instruments or the development of new analytical methods.

InChI:InChI=1/C16H16O3/c1-18-14-7-3-12(4-8-14)11-16(17)13-5-9-15(19-2)10-6-13/h3-10H,11H2,1-2H3

Upstream product

• 65850-92-2 2-hydroxy-2,3-bis-(4-methoxy-phenyl)-propionic acid 
• 65564-55-8 2-methoxy-1,2-bis(4-methoxyphenyl)ethan-1-one 
• 75748-09-3 (4-methoxybenzoyl)trimethylsilane 
• 100-09-4 4-methoxybenzoic acid 
• 10364-93-9 1-(4-methoxybenzoyl)-imidazole 
• 4356-69-8 1,1-bis-(4-methoxyphenyl)ethylene 
• 2132-62-9 4,4'-dimethoxydiphenylacetylene 
• 105-39-5 chloroacetic acid ethyl ester 
• 13139-86-1 4-methoxyphenyl magnesium bromide 
• 104-01-8 4-Methoxyphenylacetic acid 
• 100-66-3 methoxybenzene 
• 104-92-7 1-bromo-4-methoxy-benzene 
• 19625-79-7 N,N-dimethyl-2-(4-methoxyphenyl)ethanamide 
• 23786-14-3 4-methoxy-phenyl acetic acid methyl ester 

Downstream Products

• 103512-94-3 1,2,5,6-tetrakis-(4-methoxy-phenyl)-hexa-1,5-dien-3-yne 
• 102662-78-2 1,2-bis-(4-methoxy-phenyl)-oct-1-en-3-yne 
• 102553-64-0 3,4-bis-(4-methoxy-phenyl)-ξ-crotonic acid ethyl ester 
• 67295-37-8 3,4-bis-p-methoxyphenylbutanoic acid 
• 93098-08-9 ethyl 3-(4-methoxybenzoyl)-3-(4-methoxyphenyl)propionate 
• 79754-49-7 3-hydroxy-3,4-bis-(4-methoxy-phenyl)-butyric acid ethyl ester 
• 344268-07-1 4,5-Bis-(4-methoxy-phenyl)-3-methyl-5-oxo-pentanoic acid methyl ester 
• 67566-87-4 4,5-Bis-(4-methoxy-phenyl)-3-methyl-5-oxo-pentanoic acid tert-butyl ester 
• 67566-88-5 tert-butyl 5,6-bis(4-methoxyphenyl)-6-oxohexanoate 
• 92901-78-5 1-amino-1-(p-methoxyphenyl)-4'-methoxyacetophenone 
• 151229-01-5 1,2-bis(4-methoxyphenyl)-8-tetrahydropyranyloxy-octanone 
• 58363-64-7 (E)-1,2-Bis-(4-methoxy-phenyl)-3,7-diphenyl-hept-6-ene-1,5-dione 
• 1027039-47-9 2'-deuterio-4-([1,3]dioxolan-2-yl)-1,2-bis(4-methoxyphenyl)butan-1-one 
• 181308-92-9 (E)-β-chloro-α,β-bis(4-methoxyphenyl)acrolein 

Relevant articles and documents

Silica-supported orthophosphoric acid (OPA/SiO2): preparation, characterization, and evaluation as green reusable catalyst for pinacolic rearrangement

In this paper, we report an easy-to-prepare, cost-effective, efficient, and reusable silica-supported orthophosphoric acid (OPA) catalyst for pinacolic rearrangement. The surface properties of this catalyst were successfully characterized with the help of 31P NMR, TGA, DSC, FT-IR, titration, and microscopy. OPA, hydrogen bonded on the surface, is actually the active species and the reaction seems to occur in the liquid phase embedded in the silica support. As a consequence, the extracting solvent should be chosen with cautious to guarantee the recyclability of the catalyst. As example, pinacol rearrangement reactions were successfully realized with this catalyst and OPA/SiO2 proved to be as efficient as homogeneous orthophosphoric acid to promote the reaction of pinacol derivatives. When using dichloromethane as extracting solvent, OPA/SiO2 can be reuse up to ten times without a significant loss of activity. After ten runs, no physical damage of the catalyst has been observed by microscopy proving its suitability for such application.

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Continuous Flow Acylation of (Hetero)aryllithiums with Polyfunctional N,N-Dimethylamides and Tetramethylurea in Toluene

The continuous flow reaction of various aryl or heteroaryl bromides in toluene in the presence of THF (1.0 equiv) with sec-BuLi (1.1 equiv) provided at 25 °C within 40 sec the corresponding aryllithiums which were acylated with various functionalized N,N-

Combined Photoredox and Carbene Catalysis for the Synthesis of Ketones from Carboxylic Acids

As a key element in the construction of complex organic scaffolds, the formation of C?C bonds remains a challenge in the field of synthetic organic chemistry. Recent advancements in single-electron chemistry have enabled new methods for the formation of various C?C bonds. Disclosed herein is the development of a novel single-electron reduction of acyl azoliums for the formation of ketones from carboxylic acids. Facile construction of the acyl azolium in situ followed by a radical–radical coupling was made possible merging N-heterocyclic carbene (NHC) and photoredox catalysis. The utility of this protocol in synthesis was showcased in the late-stage functionalization of a variety of pharmaceutical compounds. Preliminary investigations using chiral NHCs demonstrate that enantioselectivity can be achieved, showcasing the advantages of this protocol over alternative methodologies.