2-AMINO-6,7-DIMETHYL-4-HYDROXY-5,6,7,8-TETRAHYDROPTERIDINE MONOHYDROCHLORIDE

Base Information

• Chemical Name: 2-AMINO-6,7-DIMETHYL-4-HYDROXY-5,6,7,8-TETRAHYDROPTERIDINE MONOHYDROCHLORIDE
• CAS No.: 945-43-7
• Molecular Formula: C₈H₁₃N₅O*2ClH
• Molecular Weight: 268.146
• Mol file: 945-43-7.mol

Synonyms:4(1H)-Pteridinone,2-amino-5,6,7,8-tetrahydro-6,7-dimethyl-, monohydrochloride (9CI);4(3H)-Pteridinone, 2-amino-5,6,7,8-tetrahydro-6,7-dimethyl-, monohydrochloride(8CI); 2-Amino-4-hydroxy-6,7-dimethyl-5,6,7,8-tetrahydropteridinehydrochloride; NSC 87950

Chemical Property of 2-AMINO-6,7-DIMETHYL-4-HYDROXY-5,6,7,8-TETRAHYDROPTERIDINE MONOHYDROCHLORIDE

Chemical Property:

• Vapor Pressure: 4.85E-05mmHg at 25°C
• Melting Point: 244-247 °C (dec.)(lit.)
• Boiling Point: 349°Cat760mmHg
• Flash Point: 164.9°C
• PSA: 96.09000
• Density: g/cm³
• LogP: 2.03800
• Storage Temp.: −20°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

6,7-Dimethyl-5,6,7,8-tetrahydropterine hydrochloride ≥95% ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 36/37/38-41-37/38
• Safety Statements: 26-36-36/37/39-39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-AMINO-6,7-DIMETHYL-4-HYDROXY-5,6,7,8-TETRAHYDROPTERIDINE MONOHYDROCHLORIDE

There total 5 articles about 2-AMINO-6,7-DIMETHYL-4-HYDROXY-5,6,7,8-TETRAHYDROPTERIDINE MONOHYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

2-amino-4-benzyloxy-6,7-dimethylpteridine (101092-03-9) → 6,7-dimethyl-5,6,7,8-tetrahydropterin-dihydrochloride (945-43-7,21248-26-0,53827-59-1,66547-54-4,66547-55-5,102069-95-4)

Guidance literature:

With hydrogen; platinum(IV) oxide; In trifluoroacetic acid; for 16h; under 760 Torr; Ambient temperature;

DOI:10.1016/S0040-4020(01)86024-5

Reference yield:

6,7-dimethyldihydropterin hydrogen sulfate (102093-98-1) → 6,7-Dimethylpterin (611-55-2) + 6,7-dimethyl-5,6,7,8-tetrahydropterin dihydrochloride (945-43-7,21248-26-0,53827-59-1,66547-54-4,66547-55-5,102069-95-4)

Guidance literature:

With hydrogenchloride; pH 3.5;

DOI:10.1016/S0040-4039(00)98709-4

Reference yield:

6,7-Dimethylpterin (611-55-2) → 6,7-dimethyl-5,6,7,8-tetrahydropterin dihydrochloride (945-43-7,21248-26-0,53827-59-1,66547-54-4,66547-55-5,102069-95-4)

Guidance literature:

With hydrogenchloride; hydrogen; platinum(IV) oxide;

DOI:10.1246/cl.1994.385

upstream raw materials:

6,7-Dimethylpterin

6,7-dimethyldihydropterin hydrogen sulfate

6,7-dimethyl-4-trimethylsiloxy-2-trimethylsilylaminopteridine

2-amino-4-benzyloxy-6,7-dimethylpteridine

Downstream raw materials:

6,7-dimethyl-5-nicotinoyl-5,6,7,8-tetrahydropterin

Refernces

• 1、 Boyle, Peter H.,Kelly, Mary F.. "HYDROGENATION OF SILYLATED PTERIDINES IN BENZENE SOLUTION". . p. 5179 - 5188. Retrieved 2007/10/02.