2-AMINO-6,7-DIMETHYL-4-HYDROXYPTERIDINE

Base Information

• Chemical Name: 2-AMINO-6,7-DIMETHYL-4-HYDROXYPTERIDINE
• CAS No.: 611-55-2
• Molecular Formula: C8H9 N5 O
• Molecular Weight: 191.192
• Hs Code.: 2933990090
• Mol file: 611-55-2.mol

Synonyms:4(1H)-Pteridinone,2-amino-6,7-dimethyl- (8CI,9CI); 4-Pteridinol, 2-amino-6,7-dimethyl- (6CI);2-Amino-4-hydroxy-6,7-dimethylpteridine;2-Amino-6,7-dimethyl-4(3H)-pteridinone;2-Amino-6,7-dimethyl-4-hydroxypteridine; 2-Amino-6,7-dimethylpteridin-4-ol;6,7-Dimethylpterin; NSC 31671

Chemical Property of 2-AMINO-6,7-DIMETHYL-4-HYDROXYPTERIDINE

Chemical Property:

• Vapor Pressure: 2.16E-07mmHg at 25°C
• Melting Point: >300 °C(lit.)
• Boiling Point: 423.9°C at 760 mmHg
• PKA: 2.68±0.40(Predicted)
• Flash Point: 210.1°C
• PSA: 97.81000
• Density: 1.65g/cm³
• LogP: 0.90560
• Storage Temp.: Refrigerator
• Solubility.: Aqueous Acid (Slightly), Aqueous Base (Slightly, heated)

Purity/Quality:

98%min ^*data from raw suppliers

6,7-Dimethylpterin ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: 6,7-Dimethylpterin, a derivative of Folic Acid (F680300) is used as a biomarker for a non-invasive cancer diagnosis. Also can function as chromophores in light sensitive proteins allowing for analysis of target cells. 6,7-Dimethylpterin, a derivative of Folic Acid (F680300) is used as a biomarker for a non-invasive cancer diagnosis. Also can function as chromophores in light sensitive proteins allowing for analysis of target cells.

Technology Process of 2-AMINO-6,7-DIMETHYL-4-HYDROXYPTERIDINE

There total 20 articles about 2-AMINO-6,7-DIMETHYL-4-HYDROXYPTERIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

4-(benzylsulfanyl)-6,7-dimethyl-2-pteridinamine (606964-90-3) → 6,7-Dimethylpterin (611-55-2)

Guidance literature:

4-(benzylsulfanyl)-6,7-dimethyl-2-pteridinamine; With 3,3-dimethyldioxirane; In acetone; for 0.25h;

With water; In acetone; for 0.666667h; Further stages.;

DOI:10.1039/b300798g

Reference yield: 89.0%

6,7-dimethyl-4-[(4-methylphenyl)sulfanyl]-2-pteridinamine (606964-91-4) → 6,7-Dimethylpterin (611-55-2)

Guidance literature:

6,7-dimethyl-4-[(4-methylphenyl)sulfanyl]-2-pteridinamine; With 3,3-dimethyldioxirane; In acetone; for 0.25h;

With water; In acetone; for 0.666667h; Further stages.;

DOI:10.1039/b300798g

Reference yield: 79.0%

2-(benzylsulfanyl)-6,7-dimethyl-4(3H)-pteridinone (606964-89-0) → 6,7-Dimethylpterin (611-55-2)

Guidance literature:

With ammonium hydroxide; at 180 ℃; for 2h;

DOI:10.1039/b300798g

upstream raw materials:

6,7-dimethyl-2,4-pteridine-2,4-diamine

2,5,6-triamino-3,4-dihydro-pyrimidine-4-sulfonic acid

dimethylglyoxal

6,7-dimethyl-4-trimethylsiloxy-2-trimethylsilylaminopteridine

Downstream raw materials:

6,7-dimethyl-5,6,7,8-tetrahydropterin dihydrochloride

copper perchlorate

6,7-dimethyl-5,6,7,8-tetrahydropterin-dihydrochloride

6,7-dimethyl-5,6,7,8-tetrahydropterin

Refernces

• 1、 Laura Dántola,Schuler, Tobias M.,Paula Denofrio,Vignoni, Mariana,Capparelli, Alberto L.,Lorente, Carolina,Thomas, Andrés H.. "Reaction between 7,8-dihydropterins and hydrogen peroxide under physiological conditions". . p. 8692 - 8699. Retrieved 2008/12/21.
• 2、 Bavetsias,Henderson,McDonald. "2-Pivalamido-3H-pyrimidin-4-one derivatives: Convenient pivalamide hydrolysis using Fe(NO3)3 in MeOH". . p. 5643 - 5644. Retrieved 2007/10/03.