2-Hydrazinocarbonylpyridine 1-oxide

Base Information

• Chemical Name: 2-Hydrazinocarbonylpyridine 1-oxide
• CAS No.: 54633-17-9
• Molecular Formula: C₆H₇N₃O₂
• Molecular Weight: 153.14
• Hs Code.: 2933990090
• Mol file: 54633-17-9.mol

Synonyms:2-(hydrazinecarbonyl)pyridine-1-oxide;1-oxy-pyridine-2-carboxylic acid hydrazide;1-Oxy-pyridin-2-carbonsaeure-hydrazid;Picolinic acid hydrazide N-oxide;Picolinsaeure-N-oxidhydrazid;2-Picolinoylhydrazid-N-oxid;

Chemical Property of 2-Hydrazinocarbonylpyridine 1-oxide

Chemical Property:

• Vapor Pressure: 0.0425mmHg at 25°C
• Boiling Point: 210.9°C at 760 mmHg
• Flash Point: 81.4°C
• PSA: 80.58000
• Density: 1.42g/cm³
• LogP: 0.80980

Purity/Quality:

99%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-Hydrazinocarbonylpyridine 1-oxide

There total 6 articles about 2-Hydrazinocarbonylpyridine 1-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.2%

1-oxy-pyridine-2-carboxylic acid methyl ester (38195-81-2) → 2-(hydrazinecarbonyl)pyridine-1-oxide (54633-17-9)

Guidance literature:

With hydrazine hydrate; In methanol; at 60 ℃; for 1.5h;

DOI:10.1021/jm00344a020

Reference yield: 85.0%

2-(ethoxycarbonyl)pyridine-1-oxide (30062-31-8) → 2-(hydrazinecarbonyl)pyridine-1-oxide (54633-17-9)

Guidance literature:

With hydrazine hydrate; In ethanol; at 20 ℃; for 7h;

DOI:10.1016/j.tetlet.2014.04.039

Reference yield:

2-Picolinic acid (98-98-6) → 2-(hydrazinecarbonyl)pyridine-1-oxide (54633-17-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 7 h

2: thionyl chloride / 7 h / 20 °C

3: hydrazine hydrate / ethanol / 7 h / 20 °C

With thionyl chloride; hydrazine hydrate; 3-chloro-benzenecarboperoxoic acid; In ethanol; dichloromethane;

DOI:10.1016/j.tetlet.2014.04.039

upstream raw materials:

2-pyridinecarboxylic acid N-oxide

1-oxy-pyridine-2-carboxylic acid methyl ester

ethyl-2-picolinate

2-(ethoxycarbonyl)pyridine-1-oxide

Downstream raw materials:

toluene-4-sulfonic acid 2-[5-amino-8-(1-oxy-pyridin-2-yl)-[1,2,4]triazolo[5,1-i]purin-3-yl]-ethyl ester

{2-Ethoxy-2-[(1-oxy-pyridine-2-carbonyl)-hydrazono]-ethyl}-carbamic acid benzyl ester

Refernces

• 1、 Yeung, Jupita M.,Corleto, Linda A.,Knaus, Edward E.. "Synthesis of N-(Carbonylamino)-1,2,3,6-tetrahydropyridines with Analgesic, Antiinflammatory, and Hyperglycemic Activity". . p. 191 - 195. Retrieved 2007/10/02.