Ellman's anion

Base Information

• Chemical Name: Ellman's anion
• CAS No.: 77874-90-9
• Molecular Formula: C7H3NO4S-2
• Molecular Weight: 197.171
• Mol file: 77874-90-9.mol

Synonyms:5'-thio-2-nitrobenzoate anion;Ellman's anion;3-carboxylato-4-nitrothiophenoxide ion;5-thio-2-nitrobenzoate;4-nitro-3-carboxylato-thiophenolate;2-nitro-5-thialatobenzoate;

Chemical Property of Ellman's anion

Chemical Property:

• PSA: 85.95000
• LogP: 0.38730

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Chromogenic reagent for determination of thiols, covalent modification of protein thiols, kinetic assays of cholinesterase and other enzyme activities.

Technology Process of Ellman's anion

There total 13 articles about Ellman's anion which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-nitro-3-carboxylato-thiophenolate methylmercury(II) + chloride (16887-00-6) → methylmercury(II) chloride (115-09-3) + 3-carboxylato-4-nitrothiophenoxide ion (77874-90-9)

Guidance literature:

With hydrogen cation; In water; react. temp.: 20°C, maintaining ionic strength with NaClO4 (I = 0.1 M), pH = 1.0 - 2.7; not isolated, detection by spectrophotometry; Kinetics;

DOI:10.1016/S0020-1693(00)90373-6

Reference yield:

5,5’-dithiobis(2-nitrobenzoate) (552-24-9) → 5-thio-2-nitrobenzoic acid (15139-21-6) + 3-carboxylato-4-nitrothiophenoxide ion (77874-90-9)

Guidance literature:

With sodium dithionite; di-C₁₈ vesicles; Tris buffer; potassium chloride; at 25 ℃; Rate constant; also Di-C₁₆ vesicles, also laced with varying ammounts cholesterol;

DOI:10.1021/jo00086a011

Reference yield:

5,5'-dithiobis-(2-nitrobenzoic acid) (69-78-3) → 3-carboxylato-4-nitrothiophenoxide ion (77874-90-9)

Guidance literature:

With sodium dithionite; Tris buffer; dioctadecyldimethylammonium chloride; In water; at 25 ℃; Rate constant; Ellman's reagent cosonicated with the surfactant or added after the sonication; different molar ratios; further reactant (L-cystein); further surfactant ((n-C₂₀H₄₁)2N^*Me₂Br^-);

DOI:10.1021/jo00022a048

upstream raw materials:

5,5'-dithiobis-(2-nitrobenzoic acid)

β-mercaptoethyltrimethylammonium iodide

5,5’-dithiobis(2-nitrobenzoate)

S-<(3-carboxy-4-nitrophenyl)thio>-2-aminoethanethiol

Downstream raw materials:

acetate

5,5'-dithiobis-(2-nitrobenzoic acid)

Refernces

• 1、 Han, Jiyeon,Lee, Hyuck Jin,Kim, Kyu Yeon,Lee, Shin Jung C.,Suh, Jong-Min,Cho, Jaeheung,Chae, Junghyun,Lim, Mi Hee. "Tuning Structures and Properties for Developing Novel Chemical Tools toward Distinct Pathogenic Elements in Alzheimer's Disease". . p. 800 - 808. Retrieved 2018.
• 2、 Huffman, Robert W.,Brown, David M.. "A Reconsideration of the Cleavage of Ellman's Reagent (5,5'-Dithiobis(2-nitrobenzoic acid)) in the Presence of Dioctadecyldimethylammonium Chloride Surfactant Vesicles". . p. 6477 - 6479. Retrieved 1991.
• 3、 Huffman, Robert W.,McBride, Phil,Brown, David M.. "On the Cleavage of Ellman's Reagent by Dithonite in the Presence of Dioctadecyldimethylammonium Chloride Surfactant Vesicles Laced with Cholesterol". . p. 1633 - 1637. Retrieved 2007/10/02.