2,4'-Dimethoxybenzophenone

Base Information

• Chemical Name: 2,4'-Dimethoxybenzophenone
• CAS No.: 5449-69-4
• Molecular Formula: C15H14O3
• Molecular Weight: 242.274
• Hs Code.: 2914509090
• Mol file: 5449-69-4.mol

Synonyms:(2-methoxyphenyl)-(4-methoxyphenyl)methanone;

Chemical Property of 2,4'-Dimethoxybenzophenone

Chemical Property:

• Vapor Pressure: 6.25E-07mmHg at 25°C
• Melting Point: 96.0 to 100.0 °C
• Refractive Index: 1.557
• Boiling Point: 409.9 °C at 760 mmHg
• Flash Point: 193.4 °C
• PSA: 35.53000
• Density: 1.123 g/cm³
• LogP: 2.93480
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%,99%, ^*data from raw suppliers

2,4''-Dimethoxybenzophenone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,4'-Dimethoxybenzophenone

There total 28 articles about 2,4'-Dimethoxybenzophenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

4-iodoanisol (529-28-2) + norbornene (498-66-8) → p-methoxyphenyl (1RS,2SR,3RS,4SR)-3-o-methoxyphenylbicyclo[2.2.1]hept-2-yl ketone + 2,4'-dimethoxybenzophenone (5449-69-4)

Guidance literature:

With tris-(o-tolyl)phosphine; palladium diacetate; In toluene; at 20 ℃; for 24h;

DOI:10.1246/bcsj.78.331

Reference yield: 87.0%

4-methoxy-benzaldehyde (123-11-5) + potassium (2-methoxyphenyl)trifluoroborate → 2,4'-dimethoxybenzophenone (5449-69-4)

Guidance literature:

With potassium carbonate; tri tert-butylphosphoniumtetrafluoroborate; bis(ethylene)rhodium(I) chloride dimer; In 1,4-dioxane; acetone; at 80 ℃;

DOI:10.1021/jo801460w

Reference yield: 86.0%

4-methoxyphenylboronic acid (5720-07-0) + ortho-anisaldehyde (135-02-4) → 2,4'-dimethoxybenzophenone (5449-69-4)

Guidance literature:

With potassium phosphate; platinacycle; pentan-3-one; In toluene; at 90 - 100 ℃;

DOI:10.1021/jo101469s

upstream raw materials:

4-[(2-hydroxyphenyl)carbonyl]phenol

dimethyl sulfate

methyl iodide

2,4'-dimethoxydiphenylmethane

Downstream raw materials:

(+/-)-Hydroxy-(2-methoxy-phenyl)-(4-methoxy-phenyl)-o-tolyl-methan

2-(4-methoxybenzyl)phenol

C₄₉H₅₀O₇

C₄₉H₄₈O₇

Refernces

• 1、 Dimirjian, Christine A.,Casti?eira Reis, Marta,Balmond, Edward I.,Turman, Nolan C.,Rodriguez, Elys P.,Di Maso, Michael J.,Fettinger, James C.,Tantillo, Dean J.,Shaw, Jared T.. "Synthesis of Spirobicyclic Pyrazoles by Intramolecular Dipolar Cycloadditions/[1s, 5s] Sigmatropic Rearrangements". supporting information. p. 7209 - 7212. Retrieved 2019/10/02.
• 2、 Soldi, Cristian,Lamb, Kellan N.,Squitieri, Richard A.,Gonzlez-Lpez, Marcos,Di Maso, Michael J.,Shaw, Jared T.. "Enantioselective intramolecular C-H insertion reactions of donor-donor metal carbenoids". supporting information. p. 15142 - 15145. Retrieved 2015/02/19.