2,4'-Dihydroxybenzophenone

Base Information

• Chemical Name: 2,4'-Dihydroxybenzophenone
• CAS No.: 606-12-2
• Molecular Formula: C13H10O3
• Molecular Weight: 214.221
• Hs Code.: 2914399090
• European Community (EC) Number: 679-969-2
• NSC Number: 2832
• DSSTox Substance ID: DTXSID80277556
• Nikkaji Number: J105.265I
• Wikidata: Q82008800
• ChEMBL ID: CHEMBL510074
• Mol file: 606-12-2.mol

Synonyms:2,4'-Dihydroxybenzophenone;606-12-2;(2-Hydroxyphenyl)(4-hydroxyphenyl)methanone;Benzophenone, 2,4'-dihydroxy-;(2-hydroxyphenyl)-(4-hydroxyphenyl)methanone;Methanone, (2-hydroxyphenyl)(4-hydroxyphenyl)-;CHEMBL510074;NSC2832;D07YPS;Benzophenone,4'-dihydroxy-;4-(2-hydroxybenzoyl)phenol;4,2'-dihydroxy-benzophenone;Oprea1_236403;SCHEMBL1568564;DTXSID80277556;NSC-2832;BDBM50262042;MFCD02181674;s9355;AS-65820;D2664;FT-0632519;(2-Hydroxyphenyl)(4-hydroxyphenyl)methanone #;T71117;A832809;(2-Hydroxyphenyl)(4-hydroxyphenyl)methanone, AldrichCPR;3-ethyl-5-methyl 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-6-methylpyridine-3,5-dicarboxylate

Chemical Property of 2,4'-Dihydroxybenzophenone

Chemical Property:

• Vapor Pressure: 1.97E-06mmHg at 25°C
• Melting Point: 146.0 to 150.0 °C
• Refractive Index: 1.647
• Boiling Point: 383.6 °C at 760 mmHg
• PKA: 7.65±0.15(Predicted)
• Flash Point: 200 °C
• PSA: 57.53000
• Density: 1.302 g/cm³
• LogP: 2.32880
• Storage Temp.: Sealed in dry,Room Temperature
• XLogP3: 3.2
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 214.062994177
• Heavy Atom Count: 16
• Complexity: 244

Purity/Quality:

98%,99%, ^*data from raw suppliers

2,4''-Dihydroxybenzophenone ^*data from reagent suppliers

Safty Information:

• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C(=C1)C(=O)C2=CC=C(C=C2)O)O
• Uses: 2,4''-Dihydroxybenzophenone is used in preparation method of anti-fog and antibacterial coating of nanocomposite material.

Technology Process of 2,4'-Dihydroxybenzophenone

There total 36 articles about 2,4'-Dihydroxybenzophenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(1α,4aβ,9aβ)-1,2,4a,9a-tetrahydro-1-methoxy-3,9-dioxo-4H-xanthene-9a-carboxaldehyde (113272-16-5) → 4-[(2-hydroxyphenyl)carbonyl]phenol (606-12-2)

Guidance literature:

With sodium acetate; In ethanol; for 0.25h; Heating;

DOI:10.1016/S0040-4020(01)86849-6

Reference yield: 47.0%

2-[(4-hydroxyphenyl)methyl]phenol (2467-03-0) → 4-[(2-hydroxyphenyl)carbonyl]phenol (606-12-2)

Guidance literature:

With palladium on activated charcoal; water; caesium carbonate; In N,N-dimethyl acetamide; at 110 ℃; for 48h; Inert atmosphere; Sealed tube;

DOI:10.1021/acs.orglett.1c04154

Reference yield: 44.0%

(8aR,10aR)-8-Methoxy-9-oxo-6-trimethylsilanyloxy-5,10a-dihydro-8H,9H-xanthene-8a-carbaldehyde (113272-11-0,113272-12-1) → 4-[(2-hydroxyphenyl)carbonyl]phenol (606-12-2)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; dichloromethane; for 24h; Ambient temperature;

DOI:10.1016/S0040-4020(01)86849-6

upstream raw materials:

2,4'-dimethoxybenzophenone

(2-hydroxyphenyl)(4-nitrophenyl)methanone

9-(4-hydroxy-phenyl)-xanthen-3-one

(2-acetoxy-phenyl)-(4-acetoxy-phenyl)-methane

Downstream raw materials:

4-allyloxy-2'-hydroxybenzophenone

[2-(6-Bromo-hexyloxy)-phenyl]-(4-methoxymethoxy-phenyl)-methanone

Refernces

• 1、 Nussbaumer, Peter,Bilban, Melitta,Billich, Andreas. "4,4′-Benzophenone-O,O′-disulfamate: A potent inhibitor of steroid sulfatase". . p. 2093 - 2095. Retrieved 2007/10/03.
• 2、 -. "Production of hydroxy arylophenones". . . Retrieved 2008/06/13.